Lck - lymphocyte protein tyrosine kinase Gene

Also Known as Lsk; Lskt; Hck-3; p56Lck; p56

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16818

Summary

Enables several functions, including CD4 receptor binding activity; protein antigen binding activity; and protein Phosphatase binding activity. Involved in release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of T cell differentiation. Located in cell-cell junction. Colocalizes with plasma membrane. Is expressed in several structures, including 2-cell stage embryo; nervous system; neural ectoderm; sensory organ; and thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human Lck (Lck proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lck Products (3)

mRNA	Protein	Name
NM_001162432.1	NP_001155904.1	proto-oncogene tyrosine-protein kinase LCK isoform a
NM_001162433.1	NP_001155905.1	proto-oncogene tyrosine-protein kinase LCK isoform b
NM_010693.3	NP_034823.1	proto-oncogene tyrosine-protein kinase LCK isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CD4 receptor binding	IPI IPI: Inferred from physical interaction	3262426	MGI
enables protein antigen binding	IPI IPI: Inferred from physical interaction	21245484	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7486703	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	24714587	MGI
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	16709819	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7499277	MGI
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	21487392	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	7499277	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	9177270	MGI
acts upstream of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	7807014	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7499277	MGI
acts upstream of or within positive regulation of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	7807014	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	21357543	MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	11254359	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	8175795	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	9169414	MGI
acts upstream of or within regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	14752163	MGI
acts upstream of or within regulation of regulatory T cell differentiation	IGI IGI: Inferred from genetic interaction	21245484	MGI
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	1505025	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	3262426	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
proto-oncogene tyrosine-protein kinase LCK	leukocyte C-terminal Src kinase lymphocyte cell-specific protein-tyrosine kinase

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.07%	Unkown
HY-13561	AZM475271	Inhibitor	99.89%	Unkown
HY-107447	N-Deshydroxyethyl Dasatinib	Ligand	97.19%	Unkown
HY-112291	SB 220025	Inhibitor	99.90%	Unkown
HY-10644	Lck inhibitor 2	Inhibitor	99.73%	Unkown
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-180888	Lck-IN-5	Inhibitor	98.09%	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-175463	LCK degrader-2	Degrader	/	Unkown
HY-112448	Lck-IN-6	Inhibitor	/	Unkown
HY-175281	SJ11646	Degrader	99.3%	Unkown
HY-175916	LCK ligand-1	Ligand	/	Unkown
HY-12299G	WH-4-023 (GMP)	Inhibitor	/	Unkown
HY-180928	LCK degrader-3	Degrader	/	Unkown
HY-179948	BTK-IN-45	Inhibitor	/	Unkown
HY-114980	BMS-279700	Inhibitor	/	Unkown
HY-163278	Lck-IN-2	Inhibitor	/	Unkown
HY-175437	MRT-7612	Degrader	/	Unkown
HY-175193	N-Deshydroxyethyl Dasatinib-C3-NH2	Inhibitor	/	Unkown
HY-176194	Antifibrotic agent 1	Inhibitor	/	Unkown
HY-133184	Aminogenistein	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown
HY-120622	BMS-243117	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lck	NCBI	NCBI:3932