1. GPCR/G Protein
    Cell Cycle/DNA Damage
  2. GPR40
    PPAR
  3. HWL-088

HWL-088 

Cat. No.: HY-130120 Purity: 98.80%
Handling Instructions

HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) . HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects.

For research use only. We do not sell to patients.

HWL-088 Chemical Structure

HWL-088 Chemical Structure

CAS No. : 2378617-96-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) . HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects[1][2].

IC50 & Target[2]

FFAR1/GPR40

18.9 nM (EC50)

PPARδ

570.9 nM (EC50)

In Vitro

HWL-088 (0.3 μM and 3μM) significantly increases insulin secretion fromMIN6 cells at 25 mM but not at 2 mM glucose. HWL-088 reveales a dose-dependent insulinotropic effect in the presence of 25-mM glucose[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HWL-088 (40 mg/kg; oral gavage; daily; for 30 days; ob/ob mice) treatment improves β-cell function by up-regulation of pancreas duodenum homeobox-1, reduces fat accumulation in adipose tissue and alleviated fatty liver in ob/ob mice. The effect of HWL-088 involves a reduction in hepatic lipogenesis and oxidative stress, increased lipoprotein lipolysis, glucose uptake, mitochondrial function and fatty acid β-oxidation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ob/ob mice[2]
Dosage: 40 mg/kg
Administration: Oral gavage; daily; for 30 days
Result: Improved β-cell function by up-regulation of pancreas duodenum homeobox-1, reduced fat accumulation in adipose tissue and alleviated fatty liver in ob/ob mice.
Molecular Weight

366.38

Formula

C₂₂H₁₉FO₄

CAS No.

2378617-96-8

SMILES

CC1=CC=CC=C1C2=CC(COC3=CC=C(OCC(O)=O)C(F)=C3)=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (682.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7294 mL 13.6470 mL 27.2941 mL
5 mM 0.5459 mL 2.7294 mL 5.4588 mL
10 mM 0.2729 mL 1.3647 mL 2.7294 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (5.68 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

HWL-088HWL088HWL 088GPR40PPARFree fatty acid receptor 1FFAR1FFA1G-protein-coupled receptor 40Peroxisome proliferator-activated receptorsPPARδanti-diabeticoralglucoselipid metabolismInhibitorinhibitorinhibit

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Product Name:
HWL-088
Cat. No.:
HY-130120
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