CA3 - carbonic anhydrase 3 Gene

Also Known as Car3; CAIII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 761

About CA3

Cytogenetic location: 8q21.2 Genomic coordinates (GRCh38): 8:85,438,859-85,449,040 (from NCBI)

This gene has 3 transcripts (splice variants), 310 orthologues and 14 paralogues. Biased expression in prostate (RPKM 78.7), fat (RPKM 38.8) and 3 other tissues.

Summary

Carbonic Anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes Carbonic Anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]

CA3 Products (1)

mRNA Protein Name
NM_005181.4 NP_005172.1 carbonic anhydrase 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carbonate dehydratase activity IDA
IDA: Inferred from direct assay
18618712 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
18618712 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CA3 Protein Structure

Carb_anhydrase

Carb_anhydrase: Eukaryotic-type carbonic anhydrase (5 - 259)

  • 0
  • 100
  • 200
  • 260 a.a.
Protein Preferred Names Protein Names

carbonic anhydrase 3

  • CA-III

CA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CA3 P07451 LXN Homo sapiens Q9BS40
Validated Y2H
32296183
Intra
CA3 P07451 HPCAL1 Homo sapiens P37235
Y2H Prey Pooling
32296183
Intra
CA3 P07451 HPCAL1 Homo sapiens P37235
Validated Y2H
32296183
Intra
CA3 P07451 HPCAL1 Homo sapiens P37235
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CA3 Proteins

Cat. No. Product Name Accession Purity
HY-P7719 Carbonic Anhydrase 3 Protein, Human (His) NP_005172.1 (M1-K260) ≥ 95%, as determined by reducing SDS-PAGE.

CA3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811244 Carbonic Anhydrase 3 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Acute Myocardial Infarction

  • Cardiac Attack

  • Heart Attack
Neuromuscular Disease

  • Neuromuscular Diseases

  • Neuromuscular Disorders

  • Neuromuscular Disorder
Intracranial Hypertension, Idiopathic

  • Pseudotumor Cerebri

  • Idiopathic Intracranial Hypertension

  • Benign Intracranial Hypertension

  • Iih

  • Benign Intracran. Hypt.
Osteopetrosis, Autosomal Recessive 3

  • Osteopetrosis With Renal Tubular Acidosis

  • Marble Brain Disease

  • OPTB3

  • Guibaud-Vainsel Syndrome

  • Carbonic Anhydrase Ii Deficiency

  • Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis

  • Autosomal Recessive Osteopetrosis 3

  • Carbonic Anhydrase 2 Deficiency

  • Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis

  • Osteopetrosis Autosomal Recessive 3

  • Autosomal Recessive Osteopetrosis Type 3

  • Guibaud Vainsel Syndrome

  • Mixed Rta

  • Mixed Renal Tubular Acidosis

  • Renal Tubular Acidosis Type 3

  • Carbonic Anhydrase Ii Deficiency Syndrome

  • Carbonic Anhydrase Ii Variant

  • Osteopetrosis, Autosomal Recessive, Type 3

  • Carbonic Anhydrase 2
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1154 Penbutolol sulfate Antagonist 98.89% Unkown
HY-116790 (-)-Penbutolol Antagonist 99.74% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-Y0282 Sodium bromide 99.2% Phase 3
HY-165492 Opc 14117 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3089A Dendrotoxin K TFA Inhibitor 99.84% Unkown
HY-100606 l-Pindolol 99.89% Unkown
HY-110023 Zimelidine dihydrochloride Inhibitor 98.08% Unkown
HY-176550 ASIC1a antagonist-1 Antagonist 98.00% Unkown
HY-110023R Zimelidine dihydrochloride (Standard) Inhibitor / Unkown
HY-118835 Zimelidine Inhibitor / Unkown
HY-121299 m-Chlorophenylbiguanide ≥90.0% Unkown
HY-P3089 Dendrotoxin K Inhibitor / Unkown
HY-P3679 Neuropeptide Y (1-24) (human) Activator / Unkown
HY-RS01769 CA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W714853 (+)-Theta-cypermethrin Ligand / Unkown
HY-118835S Zimeldine-d6 / Unkown