(-)-Penbutolol
Based on 1 publication(s) in Google Scholar
(-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.74%
- CAS No.: 38363-40-5
- 화학식: C18H29NO2
- 분자량:291.43
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (-)-Penbutolol
MoreAll Adrenergic Receptor Isoforms
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
제품 설명
IC50 & Target
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley rat models[3]
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Dosage:0.1-2.4 mg/kg
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Administration:iv, single dose
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Result:Upregulated the level of 5-HT in rats forebrain.
Chemical Information
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CAS No. 38363-40-5
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Appearance Solid
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분자량 291.43
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화학식 C18H29NO2
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Color White to off-white
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SMILES
O[C@H](COC1=CC=CC=C1C2CCCC2)CNC(C)(C)C
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Synonyms
(S)-Penbutolol; (-)-Isopenbutolol
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
용액&용해도
In Vitro:
DMSO : ≥ 100 mg/mL (343.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12. [Content Brief]
[2]. M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762. [Content Brief]
[3]. Gartside SE, et al., Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. Br J Pharmacol. 1999 May;127(1):145-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4314 mL | 17.1568 mL | 34.3136 mL | 85.7839 mL |
| 5 mM | 0.6863 mL | 3.4314 mL | 6.8627 mL | 17.1568 mL | |
| 10 mM | 0.3431 mL | 1.7157 mL | 3.4314 mL | 8.5784 mL | |
| 15 mM | 0.2288 mL | 1.1438 mL | 2.2876 mL | 5.7189 mL | |
| 20 mM | 0.1716 mL | 0.8578 mL | 1.7157 mL | 4.2892 mL | |
| 25 mM | 0.1373 mL | 0.6863 mL | 1.3725 mL | 3.4314 mL | |
| 30 mM | 0.1144 mL | 0.5719 mL | 1.1438 mL | 2.8595 mL | |
| 40 mM | 0.0858 mL | 0.4289 mL | 0.8578 mL | 2.1446 mL | |
| 50 mM | 0.0686 mL | 0.3431 mL | 0.6863 mL | 1.7157 mL | |
| 60 mM | 0.0572 mL | 0.2859 mL | 0.5719 mL | 1.4297 mL | |
| 80 mM | 0.0429 mL | 0.2145 mL | 0.4289 mL | 1.0723 mL | |
| 100 mM | 0.0343 mL | 0.1716 mL | 0.3431 mL | 0.8578 mL |
(-)-Penbutolol Related Classifications
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