Cat. No.: HY-116790

(-)-Penbutolol

(Synonyms: (S)-Penbutolol; (-)-Isopenbutolol)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

(-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with K_i values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3.

For research use only. We do not sell to patients.

Purity: 99.74%
CAS No.: 38363-40-5
Formula: C₁₈H₂₉NO₂
Molecular Weight:291.43

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(-)-Penbutolol Chemical Structure

CAS No.: 38363-40-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with K_i values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3^[1]^[2].

IC₅₀ & Target

β-adrenoceptor, 5-HT receptor^[1]^[2]

All Adrenergic Receptor Isoforms :

All 5-HT Receptor Isoforms :

In Vivo

(-)-Penbutolol (0.1-2.4 mg/kg, iv, single dose) inhibits 5-HT cell discharge, enhances the effect of Paroxetine (HY-122272) on the elevation of 5-HT levels in rats models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley rat models^[3]
Dosage:

0.1-2.4 mg/kg
Administration:

iv, single dose
Result:

Upregulated the level of 5-HT in rats forebrain.

Chemical Information

CAS No. 38363-40-5
Appearance Solid
Molecular Weight 291.43
Formula C₁₈H₂₉NO₂
Color White to off-white
SMILES

O[C@H](COC1=CC=CC=C1C2CCCC2)CNC(C)(C)C
Synonyms

(S)-Penbutolol; (-)-Isopenbutolol
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All

Sort by:

Journal Impact Factor

J Pharm Biomed Anal

Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]

2021 Feb 20:195:113870. PMID: 33453569

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (343.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4314 mL

17.1568 mL

34.3136 mL

5 mM

0.6863 mL

3.4314 mL

6.8627 mL

10 mM

0.3431 mL

1.7157 mL

3.4314 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12. [Content Brief]

[2]. M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762. [Content Brief]

[3]. Gartside SE, et al., Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. Br J Pharmacol. 1999 May;127(1):145-52. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4314 mL	17.1568 mL	34.3136 mL	85.7839 mL
	5 mM	0.6863 mL	3.4314 mL	6.8627 mL	17.1568 mL
	10 mM	0.3431 mL	1.7157 mL	3.4314 mL	8.5784 mL
	15 mM	0.2288 mL	1.1438 mL	2.2876 mL	5.7189 mL
	20 mM	0.1716 mL	0.8578 mL	1.7157 mL	4.2892 mL
	25 mM	0.1373 mL	0.6863 mL	1.3725 mL	3.4314 mL
	30 mM	0.1144 mL	0.5719 mL	1.1438 mL	2.8595 mL
	40 mM	0.0858 mL	0.4289 mL	0.8578 mL	2.1446 mL
	50 mM	0.0686 mL	0.3431 mL	0.6863 mL	1.7157 mL
	60 mM	0.0572 mL	0.2859 mL	0.5719 mL	1.4297 mL
	80 mM	0.0429 mL	0.2145 mL	0.4289 mL	1.0723 mL
	100 mM	0.0343 mL	0.1716 mL	0.3431 mL	0.8578 mL

Keywords

(-)-Penbutolol

1 Cited Publications

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

(-)-Penbutolol

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Neurotransmitter Receptor Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Alzheimer's Disease Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Obesity Compound Library

Antidepressant Compound Library

5-HT Receptor Compound Library

Coagulation and Anti-coagulation Compound Library

Off-patent Drug Library

Antihypertensive Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Chinese Baijiu Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) (-)-Penbutolol

All Adrenergic Receptor Isoforms

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

(-)-Penbutolol

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Neurotransmitter Receptor Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Alzheimer's Disease Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Obesity Compound Library

Antidepressant Compound Library

5-HT Receptor Compound Library

Coagulation and Anti-coagulation Compound Library

Off-patent Drug Library

Antihypertensive Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Chinese Baijiu Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) (-)-Penbutolol

All Adrenergic Receptor Isoforms

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

(-)-Penbutolol Related Classifications

HY-116790 Related Classifications