(-)-Penbutolol (Synonyms: (S)-Penbutolol; (-)-Isopenbutolol)

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(-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with K_i values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3. (-)-Penbutolol can increase hippocampal 5-HT output.

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(-)-Penbutolol Chemical Structure

CAS No. : 38363-40-5

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α adrenergic receptor β adrenergic receptor

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

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Description	(-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with K_i values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3. (-)-Penbutolol can increase hippocampal 5-HT output^[1]^[2].
IC₅₀ & Target	β-adrenoceptor, 5-HT receptor^[1]^[2]
Molecular Weight	291.43
Formula	C₁₈H₂₉NO₂
CAS No.	38363-40-5
SMILES	O[C@H](COC1=CC=CC=C1C2CCCC2)CNC(C)(C)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12. [Content Brief] [2]. M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762.

(-)-Penbutolol Related Classifications

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(-)-Penbutolol38363-40-5(S)-Penbutolol (-)-IsopenbutololAdrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptorcornu ammonishippocampalInhibitorinhibitorinhibit

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(-)-Penbutolol (Synonyms: (S)-Penbutolol; (-)-Isopenbutolol)

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