(-)-Penbutolol
Based on 1 publication(s) in Google Scholar
(-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3.
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- 純度 : 99.74%
- CAS 番号: 38363-40-5
- 分子式: C18H29NO2
- 分子量:291.43
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 (-)-Penbutolol
MoreAdrenergic Receptor アイソフォーム固有の製品をすべて表示
More5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley rat models[3]
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Dosage:0.1-2.4 mg/kg
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Administration:iv, single dose
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Result:Upregulated the level of 5-HT in rats forebrain.
化学情報
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CAS 番号 38363-40-5
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性状 Solid
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分子量 291.43
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分子式 C18H29NO2
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Color White to off-white
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SMILES
O[C@H](COC1=CC=CC=C1C2CCCC2)CNC(C)(C)C
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別名
(S)-Penbutolol; (-)-Isopenbutolol
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (343.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12. [Content Brief]
[2]. M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762. [Content Brief]
[3]. Gartside SE, et al., Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. Br J Pharmacol. 1999 May;127(1):145-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4314 mL | 17.1568 mL | 34.3136 mL | 85.7839 mL |
| 5 mM | 0.6863 mL | 3.4314 mL | 6.8627 mL | 17.1568 mL | |
| 10 mM | 0.3431 mL | 1.7157 mL | 3.4314 mL | 8.5784 mL | |
| 15 mM | 0.2288 mL | 1.1438 mL | 2.2876 mL | 5.7189 mL | |
| 20 mM | 0.1716 mL | 0.8578 mL | 1.7157 mL | 4.2892 mL | |
| 25 mM | 0.1373 mL | 0.6863 mL | 1.3725 mL | 3.4314 mL | |
| 30 mM | 0.1144 mL | 0.5719 mL | 1.1438 mL | 2.8595 mL | |
| 40 mM | 0.0858 mL | 0.4289 mL | 0.8578 mL | 2.1446 mL | |
| 50 mM | 0.0686 mL | 0.3431 mL | 0.6863 mL | 1.7157 mL | |
| 60 mM | 0.0572 mL | 0.2859 mL | 0.5719 mL | 1.4297 mL | |
| 80 mM | 0.0429 mL | 0.2145 mL | 0.4289 mL | 1.0723 mL | |
| 100 mM | 0.0343 mL | 0.1716 mL | 0.3431 mL | 0.8578 mL |
(-)-Penbutolol 関連分類
HY-116790 関連分類
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