(-)-Penbutolol (Synonyms: (S)-Penbutolol; (-)-Isopenbutolol)

Name: (-)-Penbutolol
Brand: MedChemExpress
SKU: HY-116790
Rating: 4.5 (1 reviews)

Cat. No.: HY-116790 Purity: 99.74%: Data Sheet
COA

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(-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with K_i values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3.

For research use only. We do not sell to patients.

(-)-Penbutolol Chemical Structure

CAS No. : 38363-40-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (-)-Penbutolol:

(+)-Penbutolol In-stock
Penbutolol sulfate In-stock

1 Publications Citing Use of MCE (-)-Penbutolol

•J Pharm Biomed Anal. 2021 Feb 20:195:113870.

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α adrenergic receptor β adrenergic receptor

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

(-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with K_i values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3^[1]^[2].

IC₅₀ & Target

β-adrenoceptor, 5-HT receptor^[1]^[2]

In Vivo

(-)-Penbutolol (0.1-2.4 mg/kg, iv, single dose) inhibits 5-HT cell discharge, enhances the effect of Paroxetine (HY-122272) on the elevation of 5-HT levels in rats models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague Dawley rat models^[3]
Dosage:	0.1-2.4 mg/kg
Administration:	iv, single dose
Result:	Upregulated the level of 5-HT in rats forebrain.

Molecular Weight

291.43

Formula

C₁₈H₂₉NO₂

CAS No.

38363-40-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@H](COC1=CC=CC=C1C2CCCC2)CNC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (343.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4314 mL	17.1568 mL	34.3136 mL
5 mM	0.6863 mL	3.4314 mL	6.8627 mL
10 mM	0.3431 mL	1.7157 mL	3.4314 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.74%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (249 KB) HNMR (231 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12. [Content Brief]

[2]. M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762. [Content Brief]

[3]. Gartside SE, et al., Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. Br J Pharmacol. 1999 May;127(1):145-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4314 mL	17.1568 mL	34.3136 mL	85.7839 mL
	5 mM	0.6863 mL	3.4314 mL	6.8627 mL	17.1568 mL
	10 mM	0.3431 mL	1.7157 mL	3.4314 mL	8.5784 mL
	15 mM	0.2288 mL	1.1438 mL	2.2876 mL	5.7189 mL
	20 mM	0.1716 mL	0.8578 mL	1.7157 mL	4.2892 mL
	25 mM	0.1373 mL	0.6863 mL	1.3725 mL	3.4314 mL
	30 mM	0.1144 mL	0.5719 mL	1.1438 mL	2.8595 mL
	40 mM	0.0858 mL	0.4289 mL	0.8578 mL	2.1446 mL
	50 mM	0.0686 mL	0.3431 mL	0.6863 mL	1.7157 mL
	60 mM	0.0572 mL	0.2859 mL	0.5719 mL	1.4297 mL
	80 mM	0.0429 mL	0.2145 mL	0.4289 mL	1.0723 mL
	100 mM	0.0343 mL	0.1716 mL	0.3431 mL	0.8578 mL

(-)-Penbutolol Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Penbutolol38363-40-5(S)-Penbutolol (-)-IsopenbutololAdrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptorcornu ammonishippocampalInhibitorinhibitorinhibit

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(-)-Penbutolol (Synonyms: (S)-Penbutolol; (-)-Isopenbutolol)

Customer Review

Other Forms of (-)-Penbutolol:

(-)-Penbutolol Related Antibodies

1 Publications Citing Use of MCE (-)-Penbutolol

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Adrenergic Receptor Isoform Specific Products:

View All 5-HT Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

(-)-Penbutolol Related Classifications

Keywords:

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Customer Review

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