1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. (+)-Penbutolol

(+)-Penbutolol (Synonyms: (R)-Penbutolol; (+)-Isopenbutolol)

Cat. No.: HY-116790A Purity: ≥95.0%
Handling Instructions

(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action.

For research use only. We do not sell to patients.

(+)-Penbutolol Chemical Structure

(+)-Penbutolol Chemical Structure

CAS No. : 38363-41-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 165 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].

IC50 & Target

IC50: 0.74 μM (β-adrenoceptor)[1].

In Vitro

(+)-penbutolol on the [Ca2+]i-increase induced by LPC is concentration-dependent[1].
(+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10-6 M, 5×10-6 M and 10-5 M, respectively)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

291.43

Formula

C₁₈H₂₉NO₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (343.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4314 mL 17.1568 mL 34.3136 mL
5 mM 0.6863 mL 3.4314 mL 6.8627 mL
10 mM 0.3431 mL 1.7157 mL 3.4314 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
(+)-Penbutolol
Cat. No.:
HY-116790A
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