38363-41-6
38363-41-6
Chemical Structure
(+)-Penbutolol
Synonym(s): (R)-Penbutolol; (+)-Isopenbutolol
- CAS No.: 38363-41-6
- Formula:C18H29NO2
- Molecular Weight:291.43
IUPAC Name: (R)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol
InChIKey: KQXKVJAGOJTNJS-OAHLLOKOSA-N
SMILES: O[C@@H](COC1=C(C=CC=C1)C2CCCC2)CNC(C)(C)C
Biological Activity: (+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].
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(+)-Penbutolol | 95.0% | (+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action. | ||||||||||||||||||||
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References
- [1]. Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70. [Content Brief]
- [2]. Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271(1):1-8. [Content Brief]
Keywords
