38363-40-5
38363-40-5
Chemical Structure
(-)-Penbutolol
Synonym(s): (S)-Penbutolol; (-)-Isopenbutolol
- CAS No.: 38363-40-5
- Formula:C18H29NO2
- Molecular Weight:291.43
IUPAC Name: (S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol
InChIKey: KQXKVJAGOJTNJS-HNNXBMFYSA-N
SMILES: O[C@H](COC1=CC=CC=C1C2CCCC2)CNC(C)(C)C
Biological Activity: (-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(-)-Penbutolol | 99.74% | (-)-Penbutolol ((S)-Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3. | ||||||||||||||||||||
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References
- [1]. Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12. [Content Brief]
- [2]. M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762. [Content Brief]
