2. GPCR/G Protein
    Neuronal Signaling
  3. 5-HT Receptor
    Adrenergic Receptor
  4. l-Pindolol

l-Pindolol  (Synonyms: (-)-Pindolol; (S)-(-)-Pindolol; S-Pindolol)

Cat. No.: HY-100606 Purity: 99.89%
COA Handling Instructions

l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease.

For research use only. We do not sell to patients.

l-Pindolol Chemical Structure

l-Pindolol Chemical Structure

CAS No. : 26328-11-0

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Solution
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 198 In-stock
Estimated Time of Arrival: December 31
Solid
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Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease[1][2][3].

In Vitro

l-Pindolol (500 nM and 1 μM) antagonizes the hyperpolarizing effect of both 5-carboxamidotryptamine (5-CT; 10 nM) and 5-Hydroxytryptamine (5-HT; 15 μM) by testing the membrane hyperpolarization induced by 5-CT or 5-HT on CA1 pyramidal cells[1].
l-Pindolol (1 nM-100 μM) inhibits the hyperpolarization in the hippocampus of CA1 pyramidal cells that induced by 100 nM 5-CT with an IC50 value of 92 nM[1].
l-Pindolol (1 nM-100 μM) inhibits the hyperpolarization of CA3 neurones induced by 300 nM 5-CT with an IC50 value of 522 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

l-Pindolol (15 mg/kg; i.p., pretreatment before [3H]-WAY 100635 injection) reduces [3H]-WAY 100635 accumulation of 5-HT1A receptor-containing brain areas[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats[1]
Dosage: 15 mg/kg
Administration: Intraperitoneal injection; 15 mg/kg, 20 min acute treatment or 24 h, 16 h and 20 min short-term treatment before [3H]-WAY 100635 injection
Result: Reduced [3H]-WAY 100635 accumulation in 5-HT1A receptor-containing brain areas, but showed no effect on the dorsal raphe nucleus (DRN), and the CA1 and CA3 hippocampal areas.
Molecular Weight

248.32

Appearance

Solid

Formula

C14H20N2O2
CAS No.
SMILES

O[[email protected]@H](CNC(C)C)COC1=CC=CC2=C1C=CN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (402.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0271 mL 20.1353 mL 40.2706 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL
10 mM 0.4027 mL 2.0135 mL 4.0271 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

l-Pindolol26328-11-0(-)-Pindolol (S)-(-)-Pindolol S-Pindolol5-HT ReceptorAdrenergic ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorreversiblecompetitiveoral5-CT5-HTCA1CA3Inhibitorinhibitorinhibit

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