(+)-Theta-cypermethrin 

(+)-Theta-cypermethrin is a stereoisomer of Cypermethrin (HY-B0829) that possesses blood-brain barrier penetration ability and binds to AKT1, SRC, STAT3 and EGFR with high affinity. (+)-Theta-cypermethrin reduces the amplitude of delayed rectifier potassium channel currents, shifts the steady-state activation curve to negative potentials, and shifts the steady-state inactivation curve to negative potentials at higher concentrations. (+)-Theta-cypermethrin induces abnormal electrical activity in rat hippocampal neurons. (+)-Theta-cypermethrin causes chronic respiratory system damage and exhibits neurotoxicity^[1][2].

(+)-Theta-cypermethrin (10^-9-10^-7 M; applied via perfusion during electrophysiological recording) inhibits delayed rectifier potassium current (I_k) in rat hippocampal CA3 neurons in vitro in a concentration-dependent manner, reduces I_k amplitude by up to 53.28% at 10^-7 M, shifts steady-state activation and inactivation curves toward negative potentials, and reduces the activation curve slope factor at 10^-7 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

416.30

C₂₂H₁₉Cl₂NO₃

65732-07-2

C(O[C@H](C#N)C1=CC(OC2=CC=CC=C2)=CC=C1)(=O)[C@@H]3[C@@H](C=C(Cl)Cl)C3(C)C

Room temperature in continental US; may vary elsewhere.

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• [1]. Tian YT, et al. Effect of alpha-cypermethrin and theta-cypermethrin on delayed rectifier potassium currents in rat hippocampal neurons. Neurotoxicology. 2009;30(2):269-273.

  [2]. Tian J, et al. Network toxicological mechanism analysis of pyrethroid insecticides-induced chronic respiratory system damage in humans. Ecotoxicol Environ Saf. 2025;303:118828.