65732-07-2
Chemical Structure
(+)-Theta-cypermethrin
- CAS No.: 65732-07-2
- Formula:C22H19Cl2NO3
- Molecular Weight:416.30
IUPAC Name: (S)-cyano(3-phenoxyphenyl)methyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylate
InChIKey: KAATUXNTWXVJKI-GGPKGHCWSA-N
SMILES: C(O[C@H](C#N)C1=CC(OC2=CC=CC=C2)=CC=C1)(=O)[C@@H]3[C@@H](C=C(Cl)Cl)C3(C)C
Biological Activity: (+)-Theta-cypermethrin is a stereoisomer of Cypermethrin (HY-B0829) that possesses blood-brain barrier penetration ability and binds to AKT1, SRC, STAT3 and EGFR with high affinity. (+)-Theta-cypermethrin reduces the amplitude of delayed rectifier potassium channel currents, shifts the steady-state activation curve to negative potentials, and shifts the steady-state inactivation curve to negative potentials at higher concentrations. (+)-Theta-cypermethrin induces abnormal electrical activity in rat hippocampal neurons. (+)-Theta-cypermethrin causes chronic respiratory system damage and exhibits neurotoxicity[1][2].
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(+)-Theta-cypermethrin | (+)-Theta-cypermethrin is a stereoisomer of Cypermethrin (HY-B0829) that possesses blood-brain barrier penetration ability and binds to AKT1, SRC, STAT3 and EGFR with high affinity. (+)-Theta-cypermethrin reduces the amplitude of delayed rectifier potassium channel currents, shifts the steady-state activation curve to negative potentials, and shifts the steady-state inactivation curve to negative potentials at higher concentrations. (+)-Theta-cypermethrin induces abnormal electrical activity in rat hippocampal neurons. (+)-Theta-cypermethrin causes chronic respiratory system damage and exhibits neurotoxicity. | |||||||||||||||||||||
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- [1]. Tian YT, et al. Effect of alpha-cypermethrin and theta-cypermethrin on delayed rectifier potassium currents in rat hippocampal neurons. Neurotoxicology. 2009;30(2):269-273. [Content Brief]
- [2]. Tian J, et al. Network toxicological mechanism analysis of pyrethroid insecticides-induced chronic respiratory system damage in humans. Ecotoxicol Environ Saf. 2025;303:118828. [Content Brief]
Keywords
