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Cat. No.: HY-149710

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POP-3MB

POP-3MB (compound 1b) is an ICMT inhibitor (IC₅₀: 2.5 μM). POP-3MB changes the subcellular localization of K-Ras and inhibits Ras activation. POP-3MB also inhibits Erk phosphorylation.

For research use only. We do not sell to patients.

CAS No.: 1144114-27-1
Formula: C₃₈H₃₉NO₄S
Molecular Weight:605.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

POP-3MB Chemical Structure

CAS No.: 1144114-27-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

POP-3MB (compound 1b) is an ICMT inhibitor (IC₅₀: 2.5 μM). POP-3MB changes the subcellular localization of K-Ras and inhibits Ras activation. POP-3MB also inhibits Erk phosphorylation^[1].

IC₅₀ & Target

IC50: 2.5 μM (ICMT)^[1]

All ERK Isoforms :

Chemical Information

CAS No. 1144114-27-1
Molecular Weight 605.79
Formula C₃₈H₃₉NO₄S
SMILES

O=C(N[C@@H](CSC/C=C(C/C=C(C)/C)/CCC1=CC=C(C2=CC=CC=C2)C=C1)C(O)=O)C(C=CC=C3)=C3OC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Majmudar JD et al. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem. 2012 Jan 1;20(1):283-95. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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POP-3MB

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

POP-3MB Related Classifications

HY-149710 Related Classifications