NOD1 - nucleotide binding oligomerization domain containing 1 Gene

Also Known as CARD4; NLRC1; CLR7.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10392

About NOD1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,424,527-30,478,784 (from NCBI)

This gene has 8 transcripts (splice variants), 201 orthologues and 20 paralogues. Ubiquitous expression in lung (RPKM 5.7), spleen (RPKM 4.5) and 24 other tissues.

Summary

This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds Bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic Infection. Major structural features of this protein include an N-terminal Caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]

NOD1 Products (35)

mRNA	Protein	Name
XR_926910.2
XM_047419766.1	XP_047275722.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X6
NM_001354849.2	NP_001341778.1	nucleotide-binding oligomerization domain-containing protein 1 isoform 2
XM_047419769.1	XP_047275725.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X10
XM_005249572.1	XP_005249629.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_006715633.3	XP_006715696.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419763.1	XP_047275719.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X4
XM_047419757.1	XP_047275713.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419767.1	XP_047275723.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_011515087.2	XP_011513389.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X8
XM_047419758.1	XP_047275714.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515083.2	XP_011513385.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_047419764.1	XP_047275720.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X5
NM_006092.4	NP_006083.1	nucleotide-binding oligomerization domain-containing protein 1 isoform 1
XM_047419754.1	XP_047275710.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XR_001744530.2
XM_047419752.1	XP_047275708.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_005249576.1	XP_005249633.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X11
XM_005249568.2	XP_005249625.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419760.1	XP_047275716.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419753.1	XP_047275709.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_011515085.2	XP_011513387.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419768.1	XP_047275724.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X7
XM_047419770.1	XP_047275726.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X12
XM_047419759.1	XP_047275715.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515079.1	XP_011513381.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419755.1	XP_047275711.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419756.1	XP_047275712.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515088.3	XP_011513390.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X9
XR_007059981.1
XM_011515084.2	XP_011513386.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419765.1	XP_047275721.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419761.1	XP_047275717.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419762.1	XP_047275718.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X4
NR_149002.2

NOD1 Protein Structure

CARD

NACHT

LRR_6

0
200
400
600
800
953 a.a.

Protein Preferred Names	Protein Names
nucleotide-binding oligomerization domain-containing protein 1	NLR family, CARD domain containing 1 caspase recruitment domain family, member 4 caspase recruitment domain-containing protein 4 nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1

NOD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOD1	Q9Y239	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	NOD1	Q9Y239	RIPK2	Homo sapiens	O43353	Lumier	37398436
Intra	NOD1	Q9Y239	RIPK2	Homo sapiens	O43353	Anti Tag CoIP	17054981
Intra	NOD1	Q9Y239	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	NOD1	Q9Y239	PAK1	Homo sapiens	Q13153	Validated Y2H	32814053
Intra	NOD1	Q9Y239	PAK1	Homo sapiens	Q13153	Y2H Pooling	32814053
Intra	NOD1	Q9Y239	PAK1	Homo sapiens	Q13153	Y2H Array	32814053
Intra	NOD1	Q9Y239	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	NOD1	Q9Y239	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	NOD1	Q9Y239	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	NOD1	Q9Y239	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	NOD1	Q9Y239	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	NOD1	Q9Y239	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	NOD1	Q9Y239	SUGT1	Homo sapiens	Q9Y2Z0	Anti Tag CoIP	17420470
Intra	NOD1	Q9Y239	SUGT1	Homo sapiens	Q9Y2Z0	Anti Tag CoIP	23935490
Intra	NOD1	Q9Y239	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	NOD1	Q9Y239	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	NOD1	Q9Y239	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	NOD1	Q9Y239	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Cross	NOD1	Q9Y239	sspH2	Salmonella typhimurium	A0A0H3NF38	Anti Tag CoIP	23935490

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Chlamydia	Chlamydial Infection Chlamydia Trachomatis Infectious Disease Chlamydial Disease Chlamydia Infections
Lymphoproliferative Syndrome, X-Linked, 2	XLP2 Xiap Deficiency X-Linked Lymphoproliferative Syndrome 2 X-Linked Lymphoproliferative Disease Due To Xiap Deficiency Xiap-Related Lymphoproliferative Disease, X-Linked X-Linked Lymphoproliferative Syndrome Type 2 Xiap Deficiency Syndrome
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Enteritis, Granulomatous Crohn'S Disease Of Colon Granulomatous Colitis Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Enteritis Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Colitis
Blau Syndrome	Arthrocutaneouveal Granulomatosis Jabs Syndrome BLAUS Sarcoidosis, Early-Onset Acug Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial Eos Granulomatosis, Familial Juvenile Systemic Granulomatosis, Familial, Blau Type Familial Juvenile Systemic Granulomatosis Early Onset Sarcoidosis Synovitis Granulomatous With Uveitis And Cranial Neuropathies Early-Onset Sarcoidosis Familial Granulomatosis, Blau Type Pediatric Granulomatous Arthritis Familial Granulomatosis Blau Type Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Salmonellosis	Salmonella Infections Salmonella Infection
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Duodenal Ulcer	Stress Ulcer Curling Ulcer Stress Ulcer Of Stomach Curling'S Ulcers Duodenal Ulcer Disease Duodenal Ulcers Duodenal Peptic Ulcer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18639	Nodinitib-1	Inhibitor	99.94%	Unkown
HY-100691	NOD-IN-1	Inhibitor	99.48%	Unkown
HY-P5522A	TriDAP dihydrochloride	Activator	99.16%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	Unkown
HY-168024	NOD1/2-IN-1	Inhibitor	/	Unkown
HY-184473	NOD1/TLR7 agonist-1	Agonist	/	Unkown
HY-101927	NOD1/2 antagonist-2	Antagonist	/	Unkown
HY-123925	CSLP43	Inhibitor	/	Unkown
HY-P5522	TriDAP	Activator	/	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown
HY-168023	NOD1-IN-1	Inhibitor	/	Unkown
HY-184472	NOD1 agonist-1	Agonist	/	Unkown
HY-178899	C14-Tri-LAN-Gly	Agonist	/	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown
HY-170447	NOD1 antagonist-2	Antagonist	/	Unkown
HY-159965	NOD1-RIPK2-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NOD1	RGD	RGD:1562269
Mus musculus	NOD1	MGD	MGI:1341839
Canis familiaris	NOD1	VGNC	VGNC:43877
Bos taurus	NOD1	VGNC	VGNC:32150
Macaca mulatta	NOD1	VGNC	VGNC:75185
Felis catus	NOD1	VGNC	VGNC:63849
Others	NOD1	NCBI