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Cat. No.: HY-184473

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NOD1/TLR7 agonist-1

NOD1/TLR7 agonist-1 is a dual NOD1 and TLR7 agonist. NOD1/TLR7 agonist-1 exhibits adjuvant effects in mouse vaccine models and induces increased ovalbumin-specific IgG titers. NOD1/TLR7 agonist-1 can be used for research on immune-related diseases.

For research use only. We do not sell to patients.

Formula: C₄₆H₇₁N₉O₁₁
Molecular Weight:926.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOD1/TLR7 agonist-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

NOD1

TLR7

All NOD-like Receptor (NLR) Isoforms :

All Toll-like Receptor (TLR) Isoforms :

In Vitro

NOD1/TLR7 agonist-1 (N1/T7) (0.005-20 μM; 18 h) activates NOD1 in HEK-Blue hNOD1 cells only at concentrations of 1.25 μM and 20 μM^[1].
NOD1/TLR7 agonist-1 (0.01-2.5 μM; 18 h) activates TLR7 in HEK-Blue hTLR7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NOD1/TLR7 agonist-1 (79 μg; subcutaneous injection; administered on days 0-42) exhibits potent in vivo adjuvant activity, inducing significantly higher OVA-specific total IgG titers and a Th1-skewed immune response compared with OVA without adjuvant or NOD1 agonist alone^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NIH/OlaHsd (female, 2.0−2.5 months old)^[1]
Dosage:

79 μg (equimolar to individual NOD1 agonist N1 at 50 μg)
Administration:

s.c.; on days 0, 21, and 42
Result:

Induced significantly higher OVA-specific total IgG titers than OVA alone or the individual NOD1 agonist N1.
Preferentially enhanced OVA-specific IgG2a responses, indicating a Th1-biased immune profile.
Boosted OVA-specific IgG1 levels.

Chemical Information

Molecular Weight 926.11
Formula C₄₆H₇₁N₉O₁₁
SMILES

O=C(OCC)C(N)CCCC(NC(CC[C@@H](NC(CCCCCCCCCCCNC(C1=CC=C(CN2C(O)=NC3=C(N)N=C(OCCCC)N=C23)C=C1)=O)=O)C(OC)=O)=O)C(OCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Emiliano Paradiso, et al. Conjugated NOD1-Centered Dual Agonists Exhibit Modest In Vitro Immunomodulation but Potent In Vivo Adjuvanticity.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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NOD1/TLR7 agonist-1

All NOD-like Receptor (NLR) Isoforms

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NOD1/TLR7 agonist-1 Related Classifications

HY-184473 Related Classifications