NOD1/TLR7 agonist-1
NOD1/TLR7 agonist-1 is a dual NOD1 and TLR7 agonist. NOD1/TLR7 agonist-1 exhibits adjuvant effects in mouse vaccine models and induces increased ovalbumin-specific IgG titers. NOD1/TLR7 agonist-1 can be used for research on immune-related diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C46H71N9O11
- 分子量:926.11
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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NOD1 |
TLR7 |
NOD1/TLR7 agonist-1 (N1/T7) (0.005-20 μM; 18 h) activates NOD1 in HEK-Blue hNOD1 cells only at concentrations of 1.25 μM and 20 μM[1].
NOD1/TLR7 agonist-1 (0.01-2.5 μM; 18 h) activates TLR7 in HEK-Blue hTLR7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NIH/OlaHsd (female, 2.0−2.5 months old)[1]
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Dosage:79 μg (equimolar to individual NOD1 agonist N1 at 50 μg)
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Administration:s.c.; on days 0, 21, and 42
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Result:Induced significantly higher OVA-specific total IgG titers than OVA alone or the individual NOD1 agonist N1.
Preferentially enhanced OVA-specific IgG2a responses, indicating a Th1-biased immune profile.
Boosted OVA-specific IgG1 levels.
化学情報
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分子量 926.11
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分子式 C46H71N9O11
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SMILES
O=C(OCC)C(N)CCCC(NC(CC[C@@H](NC(CCCCCCCCCCCNC(C1=CC=C(CN2C(O)=NC3=C(N)N=C(OCCCC)N=C23)C=C1)=O)=O)C(OC)=O)=O)C(OCC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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