NOD1/TLR7 agonist-1
NOD1/TLR7 agonist-1 is a dual NOD1 and TLR7 agonist. NOD1/TLR7 agonist-1 exhibits adjuvant effects in mouse vaccine models and induces increased ovalbumin-specific IgG titers. NOD1/TLR7 agonist-1 can be used for research on immune-related diseases.
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- Formule: C46H71N9O11
- Masse moléculaire:926.11
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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NOD1 |
TLR7 |
NOD1/TLR7 agonist-1 (N1/T7) (0.005-20 μM; 18 h) activates NOD1 in HEK-Blue hNOD1 cells only at concentrations of 1.25 μM and 20 μM[1].
NOD1/TLR7 agonist-1 (0.01-2.5 μM; 18 h) activates TLR7 in HEK-Blue hTLR7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NIH/OlaHsd (female, 2.0−2.5 months old)[1]
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Dosage:79 μg (equimolar to individual NOD1 agonist N1 at 50 μg)
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Administration:s.c.; on days 0, 21, and 42
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Result:Induced significantly higher OVA-specific total IgG titers than OVA alone or the individual NOD1 agonist N1.
Preferentially enhanced OVA-specific IgG2a responses, indicating a Th1-biased immune profile.
Boosted OVA-specific IgG1 levels.
Chemical Information
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Masse moléculaire 926.11
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Formule C46H71N9O11
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SMILES
O=C(OCC)C(N)CCCC(NC(CC[C@@H](NC(CCCCCCCCCCCNC(C1=CC=C(CN2C(O)=NC3=C(N)N=C(OCCCC)N=C23)C=C1)=O)=O)C(OC)=O)=O)C(OCC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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