NOD1 antagonist-2
NOD1 antagonist-2 (compound 66) is an orally active selective antagonist of both human and mouse NOD1. NOD1 antagonist-2 (compound 66) antagonizes NOD1-induced NF-κB and MAPK pathways.
For research use only. We do not sell to patients.
- Formula: C21H13Cl2F2N3O5S2
- Molecular Weight:560.38
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
hNOD1 0.8 nM (IC50, in HEK293 cells) |
mNOD1 32 nM (IC50, in HEK293 cells) |
NOD1 antagonist-2 (compound 66) demonstrates promising antagonistic activity against both h/mNOD1-induced NF-κB activation in HEK293 cells (IC50 = 0.8 nM and 32 nM, respectively)[1].
NOD1 antagonist-2 (compound 66, 0.1, 1 μM) markedly inhibits the increases in p-RIP2, p-p65, p-p38, and p-JNK of both THP-1 cells and mBMDMs, demonstrating its efficacy in modulating NOD1-induced signaling pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 560.38
-
Formula C21H13Cl2F2N3O5S2
-
SMILES
CS(C1=CC=C(N=C(Cl)N(C2=CC(NS(=O)(C3=C(F)C=CC=C3F)=O)=C(Cl)C=C2)C4=O)C4=C1)(=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOD1 antagonist-2 Related Classifications
HY-170447 Related Classifications
Powered by Bioz