Cat. No.: HY-N7922

Urolithin M5

(Synonyms: Decarboxyellagic acid)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease.

For research use only. We do not sell to patients.

Purity: 97.31%
CAS No.: 91485-02-8
Formula: C₁₃H₈O₇
Molecular Weight:276.20

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Urolithin M5 Chemical Structure

CAS No.: 91485-02-8

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(In Japan)

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All p38 MAPK Isoforms :

All EGFR Isoforms :

All Akt Isoforms :

In Vitro

Urolithin M5 (two-fold dilution series; 48 h) exhibits cytotoxicity against MDCK cells with a CC₅₀ of 227.4 μM^[1].
Urolithin M5 (5-500 μM; 30 min virus pre-incubation, 30 min erythrocyte incubation) does not inhibit hemagglutination induced by influenza A/WSN/33(H1N1) virus in chicken erythrocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Madin-Darby canine kidney (MDCK) cells
Concentration:

10 μM, 100 μM, 1 mM
Incubation Time:

48 h
Result:

Exhibited a CC₅₀ value of 227.4 μM against madin-Darby canine kidney (MDCK) cells.

In Vivo

Urolithin M5 (200 mg/kg/day; p.o.; once daily; 6 consecutive days) protects 50% of PR8-infected BALB/c mice from death, reduces lung edema and viral load, and lowers pro-inflammatory cytokine levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 16-18 g, intranasally infected with influenza A virus strain PR8)^[1]
Dosage:

200 mg/kg/day
Administration:

p.o.; once daily; 6 consecutive days
Result:

Protected 50% of mice from death.
Showed rebound in body weight starting at day 9.Reduced lung index from 1.445 to 0.8875.\n
Reduced lung viral titer by 0.52 log.Decreased lung tissue levels of NF-κB, TNF-α, and IL-6.
Alleviated histopathological lung lesions including reduced bronchial injury and inflammatory cell infiltration.

Chemical Information

CAS No. 91485-02-8
Appearance Solid
Molecular Weight 276.20
Formula C₁₃H₈O₇
Color White to yellow
SMILES

O=C1C2=CC(O)=C(O)C(O)=C2C3=CC=C(O)C(O)=C3O1
Synonyms

Decarboxyellagic acid
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (362.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.6206 mL

18.1028 mL

36.2056 mL

5 mM

0.7241 mL

3.6206 mL

7.2411 mL

10 mM

0.3621 mL

1.8103 mL

3.6206 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiao M, et al. Urolithin M5 from the Leaves of Canarium album (Lour.) DC. Inhibits Influenza Virus by Targeting Neuraminidase. Molecules. 2022 Sep 5;27(17):5724. [Content Brief]

[2]. Li HL, et al. Identification of ellagic acid and urolithins as natural inhibitors of Aβ_25-35-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking. Front Nutr. 2022;9:966276. Published 2022 Aug 2. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.6206 mL	18.1028 mL	36.2056 mL	90.5141 mL
	5 mM	0.7241 mL	3.6206 mL	7.2411 mL	18.1028 mL
	10 mM	0.3621 mL	1.8103 mL	3.6206 mL	9.0514 mL
	15 mM	0.2414 mL	1.2069 mL	2.4137 mL	6.0343 mL
	20 mM	0.1810 mL	0.9051 mL	1.8103 mL	4.5257 mL
	25 mM	0.1448 mL	0.7241 mL	1.4482 mL	3.6206 mL
	30 mM	0.1207 mL	0.6034 mL	1.2069 mL	3.0171 mL
	40 mM	0.0905 mL	0.4526 mL	0.9051 mL	2.2629 mL
	50 mM	0.0724 mL	0.3621 mL	0.7241 mL	1.8103 mL
	60 mM	0.0603 mL	0.3017 mL	0.6034 mL	1.5086 mL
	80 mM	0.0453 mL	0.2263 mL	0.4526 mL	1.1314 mL
	100 mM	0.0362 mL	0.1810 mL	0.3621 mL	0.9051 mL

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Urolithin M5

Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

MAPK Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

PI3K/Akt/mTOR Compound Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Antiviral Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Oxygen Sensing Compound Library

Phenols Library

Glycolysis Compound Library

Pyroptosis Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Alzheimer's Disease Compound Library

Neuroprotective Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

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Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Antiviral Traditional Chinese Medicine Active Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Anti-Drug-Resistant Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Urolithin M5

All p38 MAPK Isoforms

All EGFR Isoforms

All Akt Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Urolithin M5 Related Classifications

Cat. No.: HY-N7922