Autophagy inducer 5
Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects.
For research use only. We do not sell to patients.
- Formula: C41H52N4O3
- Molecular Weight:648.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
7 μM
Compound: 21o
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| Bel-7402 | IC50 |
3.7 μM
Compound: 21o
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Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| MCF-10A | IC50 |
15.4 μM
Compound: 21o
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Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| MCF7 | IC50 |
2 μM
Compound: 21o
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
Chemical Information
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Molecular Weight 648.88
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Formula C41H52N4O3
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SMILES
O=C([C@]1(C)CC[C@]2(C)CC[C@]3(C)[C@]4(C)C=CC5=C(C)C6=NC7=CC=C(C(NCCN(C)C)=O)C=C7N=C6C=C5C4=CC[C@@]3(C)[C@]2([H])C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Autophagy inducer 5 Related Classifications
HY-159605 Related Classifications
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