9''-Methyl lithospermic acid
9''-Methyl lithospermic acid is a serine palmitoyltransferase (SPT) activator. 9''-Methyl lithospermic acid increases the levels of SPT1 and SPT2 in human keratinocytes. 9''-Methyl lithospermic acid maintains epidermal permeability barrier function by promoting SPT expression.
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- CAS 番号: 1151683-53-2
- 分子式: C28H24O12
- 分子量:552.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
9''-Methyl lithospermic acid (Compound 2) (100 μg/mL) significantly increases SPT1 mRNA (to 139%) and SPT2 mRNA (to 139%) expression in normal human keratinocyte HaCaT cells[1].
9''-Methyl lithospermic acid (10-100 μg/mL; 9 h) dose-dependently increases SPT protein expression in normal human keratinocyte HaCaT cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT
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Concentration:10 μg/mL, 30 μg/mL, 100 μg/mL
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Incubation Time:9 h
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Result:Increased SPT protein levels to 108.9% of negative control at 10 μg/mL.
Increased SPT protein levels to 120.2% of negative control at 30 μg/mL.
Increased SPT protein levels to 123% of negative control at 100 μg/mL, showing a dose-dependent effect.
化学情報
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CAS 番号 1151683-53-2
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分子量 552.48
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分子式 C28H24O12
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SMILES
OC([C@H]1C2=C(/C=C/C(O[C@@H](C(OC)=O)CC3=CC(O)=C(C=C3)O)=O)C=CC(O)=C2O[C@@H]1C4=CC(O)=C(C=C4)O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
9''-Methyl lithospermic acid 関連分類
HY-N20677 関連分類
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