ATM Inhibitor-1
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 0.7 nM, shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM). ATM Inhibitor-1 exhibits anti-tumor activity.
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- CAS 番号: 2135639-94-8
- 分子式: C27H36N6O3
- 分子量:492.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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ATM 0.7 nM (IC50) |
ATM 2.8 nM (IC50, Cellular assay) |
PI3Kδ 0.73 μM (IC50) |
PI3Kγ 3 μM (IC50) |
PI3Kα 3.8 μM (IC50) |
PI3Kβ 10.3 μM (IC50) |
DNAPK 2.8 μM (IC50) |
mTOR 21 μM (IC50) |
ATM Inhibitor-1 (Compound 21) is a highly potent, selective and orally active ATM Inhibitor, with an IC50 of 0.7 nM, shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM)[1].
In cellular assays, ATM Inhibitor-1 exhibits IC50s of 2.8 nM, >30 μM and >19 μM for ATM, ATR/PI3Kα and PI3Kβ/mTOR, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SW620 mice model[1]
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Dosage:50 mg/kg
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Administration:P.O., once daily for 3 days every week starting 24 h post-irinotecan dosing, 21 days
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Result:Inhibited the growth of tumor combined with 50 mg/kg irinotecan in SW620 mice model.
化学情報
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CAS 番号 2135639-94-8
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分子量 492.61
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分子式 C27H36N6O3
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SMILES
C[C@@H](C1CCOCC1)NC2=C(C(NC)=O)N=NC3=CC=C(C4=CC=C(OCCCN(C)C)N=C4)C=C32
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ATM Inhibitor-1 関連分類
HY-112614 関連分類
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