Crassicauline A
Based on 1 Customer Validation
Crassicauline A (Crassicaulin A) is a diester-type diterpenoid alkaloid. Crassicauline A exhibits feeding deterrent activity against adult Tribolium castaneum, with a EC50 of 1134.5 ppm. Crassicauline A induces arrhythmia at a dose of 0.10 mg/kg.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.78%
- CAS 番号: 79592-91-9
- 分子式: C35H49NO10
- 分子量:643.76
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Crassicauline A is a compound found in the roots of Aconitum episcopale[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Crassicauline A (0.10 mg/kg; i.v.; single dose) induces severe arrhythmias including VPB, VT, and VF in normal rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tribolium castaneum (unsexed, 2 weeks old)[1]
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Dosage:10 ppm; 30 ppm; 100 ppm; 300 ppm; 1000 ppm
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Administration:/
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Result:Reduced diet consumption to 97.81% of control at 10 ppm.
Reduced diet consumption to 89.73% of control at 30 ppm.
Reduced diet consumption to 78.36% of control at 100 ppm.
Reduced diet consumption to 69.59% of control at 300 ppm.
Reduced diet consumption to 53.29% of control at 1000 ppm.
Achieved an EC50 of 1134.5 ppm for feeding reduction relative to control.
化学情報
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CAS 番号 79592-91-9
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性状 Solid
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分子量 643.76
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分子式 C35H49NO10
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Color White to off-white
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SMILES
CO[C@@H](CC[C@]1(COC)[C@@]2([H])[C@H]3OC)C42[C@@](C[C@@]5(O)[C@@H]6OC(C7=CC=C(OC)C=C7)=O)([H])[C@@]6([H])[C@](OC(C)=O)(C[C@@H]5OC)C3C4N(C1)CC
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別名
Crassicaulin A
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 100 mg/mL (155.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.88 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.88 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Liu ZL, et al. Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. J Agric Food Chem. 2011;59(8):3701-3706. [Content Brief]
[2]. Tao P, et al. Attenuation and Structural Transformation of Crassicauline A During Sand Frying Process and Antiarrhythmic Effects of its Transformed Products. Front Pharmacol. 2021;12:734671. Published 2021 Nov 2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5534 mL | 7.7669 mL | 15.5337 mL | 38.8343 mL |
| 5 mM | 0.3107 mL | 1.5534 mL | 3.1067 mL | 7.7669 mL | |
| 10 mM | 0.1553 mL | 0.7767 mL | 1.5534 mL | 3.8834 mL | |
| 15 mM | 0.1036 mL | 0.5178 mL | 1.0356 mL | 2.5890 mL | |
| 20 mM | 0.0777 mL | 0.3883 mL | 0.7767 mL | 1.9417 mL | |
| 25 mM | 0.0621 mL | 0.3107 mL | 0.6213 mL | 1.5534 mL | |
| 30 mM | 0.0518 mL | 0.2589 mL | 0.5178 mL | 1.2945 mL | |
| 40 mM | 0.0388 mL | 0.1942 mL | 0.3883 mL | 0.9709 mL | |
| 50 mM | 0.0311 mL | 0.1553 mL | 0.3107 mL | 0.7767 mL | |
| 60 mM | 0.0259 mL | 0.1294 mL | 0.2589 mL | 0.6472 mL | |
| 80 mM | 0.0194 mL | 0.0971 mL | 0.1942 mL | 0.4854 mL | |
| 100 mM | 0.0155 mL | 0.0777 mL | 0.1553 mL | 0.3883 mL |
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