(E)-Nitrofurazone
(E)-Nitrofurazone ((E)-Nitrofural) is a topical broad-spectrum antibacterial agent effective against both Gram-negative and Gram-positive bacteria. (E)-Nitrofurazone also possesses antiprotozoal and antiparasitic activities. (E)-Nitrofurazone is commonly used in the research of superficial wounds, burns, skin infections, pyoderma, infectious skin diseases, trypanosomiasis, and acute bacillary dysentery.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.83%
- CAS 番号: 112574-44-4
- 分子式: C6H6N4O4
- 分子量:198.14
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
>100 μM
Compound: NFZ
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Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay
Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay
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[PMID: 36516584] |
| THP-1 | IC50 |
>100 μM
Compound: NFZ
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Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin staining based analysis
Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin staining based analysis
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[PMID: 37859713] |
| V79 | IC50 |
270 μM
Compound: Nitrofurazone
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Differential hypoxic cytotoxicity towards chinese hamster cells (V79) using MTT assay under anaerobic conditions
Differential hypoxic cytotoxicity towards chinese hamster cells (V79) using MTT assay under anaerobic conditions
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10.1016/0960-894X(95)00352-T |
| V79 | IC50 |
740 μM
Compound: Nitrofurazone
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Differential hypoxic cytotoxicity towards chinese hamster cells (V79) using MTT assay under aerobic conditions
Differential hypoxic cytotoxicity towards chinese hamster cells (V79) using MTT assay under aerobic conditions
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10.1016/0960-894X(95)00352-T |
| Vero | IC50 |
>100 μM
Compound: NFZ
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Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay
Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay
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[PMID: 36516584] |
| Vero | IC50 |
>100 μM
Compound: NFZ
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Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based analysis
Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based analysis
|
[PMID: 37859713] |
化学情報
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CAS 番号 112574-44-4
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性状 Solid
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分子量 198.14
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分子式 C6H6N4O4
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Color Light yellow to yellow
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SMILES
O=[N+](C1=CC=C(/C=N/NC(N)=O)O1)[O-]
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別名
(E)-Nitrofural
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 6.25 mg/mL (31.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (394 KB)
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- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.0469 mL | 25.2347 mL | 50.4694 mL | 126.1734 mL |
| 5 mM | 1.0094 mL | 5.0469 mL | 10.0939 mL | 25.2347 mL | |
| 10 mM | 0.5047 mL | 2.5235 mL | 5.0469 mL | 12.6173 mL | |
| 15 mM | 0.3365 mL | 1.6823 mL | 3.3646 mL | 8.4116 mL | |
| 20 mM | 0.2523 mL | 1.2617 mL | 2.5235 mL | 6.3087 mL | |
| 25 mM | 0.2019 mL | 1.0094 mL | 2.0188 mL | 5.0469 mL | |
| 30 mM | 0.1682 mL | 0.8412 mL | 1.6823 mL | 4.2058 mL |
(E)-Nitrofurazone 関連分類
HY-B0226A 関連分類
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