Mesp2 - mesoderm posterior 2 Gene

Also Known as bHLHc6

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 17293

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mesodermal cell migration; regulation of gene expression; and somite rostral/caudal axis specification. Located in nucleus. Is expressed in several structures, including central nervous system; ear; embryo mesoderm; genitourinary system; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Mesp2 Products (1)

mRNA Protein Name
NM_008589.2 NP_032615.2 mesoderm posterior protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15902259 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15902259 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15902259 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within Notch signaling pathway IGI
IGI: Inferred from genetic interaction
15902259 MGI
acts upstream of or within Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
20346937 MGI
acts upstream of or within mesodermal cell migration IGI
IGI: Inferred from genetic interaction
10887078 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15902259 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15902259 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20346937 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of or within somite rostral/caudal axis specification IMP
IMP: Inferred from mutant phenotype
20346937 MGI
acts upstream of or within somitogenesis IGI
IGI: Inferred from genetic interaction
15902259 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
15902259 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleus IDA
IDA: Inferred from direct assay
15902259 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mesoderm posterior protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08343 MESP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Mesp2 NCBI NCBI:145873