Dot1l - DOT1-like, histone H3 methyltransferase (S. cerevisiae) Gene

Also Known as Dot1; KMT4; mDot1; A630076O07

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 208266

About Dot1l

Chromosome 10: 80,591,040-80,631,295 forward strand.GRCm39:CM001003.3

This gene has 7 transcripts (splice variants), 205 orthologues and is associated with 18 phenotypes. Ubiquitous expression in testis adult (RPKM 34.5), adrenal adult (RPKM 27.1) and 28 other tissues.

Summary

Enables Histone Methyltransferase activity. Acts upstream of or within with a negative effect on gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; blood; heart; sensory organ; and yolk sac. Used to study dilated cardiomyopathy 1A. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dot1l Products (1)

mRNA Protein Name
NM_199322.2 NP_955354.1 histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
14572310 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within negative effect gene expression IDA
IDA: Inferred from direct assay
20427473 MGI
acts upstream of or within negative effect gene expression IMP
IMP: Inferred from mutant phenotype
20427473 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
20427473 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20427473 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dot1l Protein Structure

DOT1

DOT1: pfam08123 (114 - 316)

CC_DOT1L

CC_DOT1L: cd20902 (480 - 544)

Mplasa_alph_rch

Mplasa_alph_rch: cl37461 (509 - 658)

PHA03307

PHA03307: cl33723 (780 - 1124)

Herpes_BLLF1

Herpes_BLLF1: cl37540 (941 - 1313)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1540 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase, H3 lysine-79 specific

  • DOT1-like histone H3 methyltransferase

  • histone H3 methyltransferase DOT1

  • histone methyltransferase DOT1L

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-15593 Pinometostat Inhibitor 99.99% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-15227 EPZ004777 Inhibitor 99.74% Unkown
HY-15650 SGC0946 Inhibitor 99.68% Unkown
HY-135127 Dot1L-IN-4 Inhibitor 99.67% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-15227A EPZ004777 hydrochloride Inhibitor 98.92% Unkown
HY-135128 Dot1L-IN-5 Inhibitor 99.82% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-121093 DC-S239 Inhibitor 99.73% Unkown
HY-101520A Dot1L-IN-1 TFA Inhibitor 99.59% Unkown
HY-181789 DOT1L808 Degrader 98.31% Unkown
HY-173422 MS2133 Degrader / Unkown
HY-101520 Dot1L-IN-1 Inhibitor / Unkown
HY-173423 DOT1L ligand-1 Ligand / Unkown
HY-115619 EPZ004777 formate Inhibitor / Unkown
HY-181790 DOT1L ligand-2 Ligand / Unkown
HY-168083 Dot1L-IN-9 Inhibitor / Unkown
HY-145813 MU1656 Inhibitor / Unkown
HY-146724 Dot1L-IN-7 Inhibitor / Unkown
HY-15650A SGC0946 TFA Inhibitor / Unkown
HY-111367 MS2734 Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Dot1l NCBI NCBI:84444