Otop1 - otopetrin 1 Gene

Also Known as tlt; Otp1; A530025J20Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 21906

Summary

Enables proton channel activity. Involved in cellular response to Insulin stimulus; negative regulation of interferon-gamma-mediated signaling pathway; and proton transmembrane transport. Acts upstream of or within detection of gravity and inner ear morphogenesis. Located in membrane. Is integral component of plasma membrane. Is expressed in several structures, including adrenal gland; inner ear; integumental system; stomach; and Thymus. Orthologous to human OTOP1 (otopetrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Otop1 Products (1)

mRNA Protein Name
NM_172709.3 NP_766297.2 proton channel OTOP1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables proton channel activity IDA
IDA: Inferred from direct assay
29371428 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
24379350 MGI
acts upstream of or within detection of gravity IMP
IMP: Inferred from mutant phenotype
12651873 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
12651873 MGI
involved in negative regulation of type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24379350 MGI
involved in proton transmembrane transport IDA
IDA: Inferred from direct assay
29371428 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in membrane IDA
IDA: Inferred from direct assay
12651873 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29371428 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proton channel OTOP1

  • tilted

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-179491 OTOP1-IN-1 Inhibitor / Unkown
HY-RS09864 OTOP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Otop1 NCBI NCBI:133060