SPRR1B - small proline rich protein 1B Gene

Also Known as SPRR1; GADD33; SPR-IB; CORNIFIN

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 6699

About SPRR1B

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,031,203-153,032,900 (from NCBI)

This gene has 1 transcript (splice variant), 60 orthologues and 20 paralogues. Restricted expression toward esophagus (RPKM 644.6).

Summary

The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by Transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]

SPRR1B Products (1)

mRNA Protein Name
NM_003125.3 NP_003116.2 cornifin-B

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence 参考文献 由来
involved in keratinocyte differentiation IDA
IDA: Inferred from direct assay
10908733 GOA
involved in peptide cross-linking IDA
IDA: Inferred from direct assay
10908733 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cornified envelope IDA
IDA: Inferred from direct assay
10908733 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRR1B Protein Structure

Cornifin

Cornifin: Cornifin (SPRR) family (17 - 57)

Cornifin

Cornifin: Cornifin (SPRR) family (42 - 87)

  • 0
  • 89 a.a.
Protein Preferred Names Protein Names

cornifin-B

  • 14.9 kDa pancornulin

関連疾患

Diseases Alias
Cervical Intraepithelial Neoplasia

  • CIN
Anus Benign Neoplasm

  • Anal Neoplasm

  • Anal Tumors

  • Neoplasm Of Anus

  • Anus Neoplasms
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13714 SPRR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus SPRR1B RGD RGD:1587862
Mus musculus SPRR1B MGD MGI:106659
Others SPRR1B NCBI