GSK575594A
GSK575594A is a modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR. At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum (Emax increased from 1.19 g to 1.51 g). GSK575594A may be used in research within the field of antiparasitic studies.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 909418-68-4
- 分子式: C24H23F2N3O3S
- 分子量:471.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
10 μM
Compound: GSK575594A
|
Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay
Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay
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[PMID: 26575458] |
化学情報
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CAS 番号 909418-68-4
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分子量 471.52
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分子式 C24H23F2N3O3S
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SMILES
O=C(N1CCN(C2=CC=C(N)C=C2F)CC1)C3=CC(S(=O)(C)=O)=CC=C3C4=CC=C(F)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GSK575594A 関連分類
HY-111161 関連分類
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