KRAS-IN-43
KRAS-IN-43 (Compound 9) is a pan-KRAS inhibitor with IC50 values of 0.15 μM, 0.14 μM, and 0.47 μM against KRASG12V, KRASG12C and wild-type KRAS, respectively. KRAS-IN-43 disrupts the interaction between KRAS and cRAF, and inhibits ERK phosphorylation. KRAS-IN-43 is promising for research of KRAS mutation-related cancers (such as pancreatic cancer, colorectal cancer, and lung cancer).
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- 分子式: C30H29FN2O3
- 分子量:484.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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KRas G12V 0.15 μM (IC50) |
KRas G12C 0.14 μM (IC50) |
K-Ras WT 0.47 μM (IC50) |
化学情報
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分子量 484.56
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分子式 C30H29FN2O3
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SMILES
C#CC1=C(C=CC2=CC(O)=CC(C(N3CCC4=C(C3)C=CC=C4OCC56CCCN5CCC6)=O)=C21)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KRAS-IN-43 関連分類
HY-176250 関連分類
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