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LC-SF-14

LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR (IC50 values are 71.6 and 8.9 nM, respectively). LC-SF-14 inhibits FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation. LC-SF-14 inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). LC-SF-14 has antitumor activity in the SNU-16 xenograft mouse model. LC-SF-14 can be used in FGFR2-driven gastric cancer research.

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  • 分子式: C44H50Cl3N13O5S
  • 分子量:979.38
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • LC-SF-14 Chemical Structure
    LC-SF-14 構造式
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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  • LC-SF-14 Chemical Structure
    LC-SF-14 Chemical Structure
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  • LC-SF-14