NF449 (octasodium)
Based on 7 publication(s) in Google Scholar
NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.39%
- CAS 番号: 627034-85-9
- 分子式: C41H24N6Na8O29S8
- 分子量:1505.09
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保管条件:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 NF449 octasodium
More- Cell Host Microbe. 2025 Sep 30:S1931-3128(25)00375-0. [Abstract]
- Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2318767121. [Abstract]
- EMBO J. 2025 Sep 1. [Abstract]
- J Agric Food Chem. 2026 Apr 22;74(15):12132-12144. [Abstract]
- Vet Parasitol. 2026 May:344:110769. [Abstract]
- Vet Parasitol. 2022 Dec:312:109841. [Abstract]
- bioRxiv. 2026 Jun 3.
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Bio/Physico-chemical Assay
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P2X Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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p2x1 Receptor |
NF449 octasodium suppressed the rate of GTP[γS] binding to rGsα-s while barely affecting binding to rGiα-1 (IC50=140 nM), inhibits stimulation of adenylyl cyclase activity in S49 cyc membranes (deficient in endogenous Gsα) by exogenously added Gsα-s, and blocks the coupling of β-adrenergic receptors to Gs (EC50=7.9 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 627034-85-9
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性状 Solid
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分子量 1505.09
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分子式 C41H24N6Na8O29S8
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Color White to off-white
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SMILES
O=C(NC1=CC(C(NC2=CC=C(S(=O)(O[Na])=O)C=C2S(=O)(O[Na])=O)=O)=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C=C3S(=O)(O[Na])=O)=O)=C1)NC4=CC(C(NC5=CC=C(S(=O)(O[Na])=O)C=C5S(=O)(O[Na])=O)=O)=CC(C(NC6=CC=C(S(=O)(O[Na])=O)C=C6S(=O)(O[Na])=O)=O)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (7)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation. [Abstract]2025 Sep 30:S1931-3128(25)00375-0. PMID: 41033313 -
Proc Natl Acad Sci U S A
The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells. [Abstract]2024 Oct 29;121(44):e2318767121. PMID: 39432783
NF449 octasodium purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2318767121. [Abstract]
NF449 octasodium (10 μM; 30 min), a Gsα-subunit-selective G-protein antagonist，canceled PA-induced dendrite protrusion of iPSC-derived cDC1s.
NF449 octasodium purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2318767121. [Abstract]
NF449 octasodium (10 μM; 30 min), a Gsα antagonist, abolished the significant increase in the percentage of OVA+ cells displaying antigen uptake among GPR31-expressing iPSC-derived cDC1s during PA stimulation.
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EMBO J
GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors. [Abstract]2025 Sep 1. PMID: 40890486 -
J Agric Food Chem
Preventive Effect of Caffeic Acid Phenethyl Ester, an Active Component of Propolis, against TNF-α-Induced Endothelial Dysfunction through the β2-Adrenoceptor-Mediated eNOS/NO Signal Pathway. [Abstract]2026 Apr 22;74(15):12132-12144. PMID: 41957988 -
Vet Parasitol
2026 May:344:110769. PMID: 41967379 -
Vet Parasitol
Giardia duodenalis trophozoites triggered bovine neutrophil extracellular traps formation dependent on P2X1 receptor and PAD4 in vitro. [Abstract]2022 Dec:312:109841. PMID: 36427458
NF449 octasodium purchased from MedChemExpress. Usage Cited in: Vet Parasitol. 2022 Dec:312:109841. [Abstract]
The purinergic P2X1 receptor's inhibitor NF449 octasodium (10 mM; 30 min) sharply declined Giardia duodenalis trophozoites-triggered NET formation.
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溶剤 & 溶解度
H2O : 10 mg/mL (6.64 mM; Need ultrasonic and warming)
DMSO : 10 mg/mL (6.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Rettinger J, et al. Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology. 2005;48(3):461-468. [Content Brief]
[2]. Hohenegger M, et al. Gsalpha-selective G protein antagonists. Proc Natl Acad Sci U S A. 1998;95(1):346-351. [Content Brief]
[3]. Hechler B, et al. Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. J Pharmacol Exp Ther. 2005;314(1):232-243. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.6644 mL | 3.3221 mL | 6.6441 mL | 16.6103 mL |
| 5 mM | 0.1329 mL | 0.6644 mL | 1.3288 mL | 3.3221 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NF449 octasodium 関連分類
HY-112461A 関連分類
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