Sergliflozin-A
Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 360775-96-8
- 分子式: C20H24O7
- 分子量:376.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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SGLT1 |
SGLT2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
9.2 nM
Compound: 4a
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Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
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[PMID: 18260618] |
| CHO | EC50 |
>8000 nM
Compound: 4a
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Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
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[PMID: 18260618] |
| CHO | IC50 |
6.25 nM
Compound: 6
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Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting
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[PMID: 20181486] |
| CHO | IC50 |
2300 nM
Compound: 3-active
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Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
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[PMID: 21873071] |
| CHO | IC50 |
4.8 nM
Compound: 3-active
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Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
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[PMID: 21873071] |
| CHO-K1 | IC50 |
2300 nM
Compound: 2-A
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Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay
Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay
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[PMID: 22652255] |
| CHO-K1 | IC50 |
4.8 nM
Compound: 2-A
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Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay
Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay
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[PMID: 22652255] |
化学情報
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CAS 番号 360775-96-8
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分子量 376.40
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分子式 C20H24O7
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SMILES
COC(C=C1)=CC=C1CC(C=CC=C2)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sergliflozin-A 関連分類
HY-165438 関連分類
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