1. Membrane Transporter/Ion Channel
  2. SGLT

Bexagliflozin (Synonyms: EGT1442; EGT0001442; THR-1442)

Cat. No.: HY-17604 Purity: 98.63%
Handling Instructions

Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively.

For research use only. We do not sell to patients.
Bexagliflozin Chemical Structure

Bexagliflozin Chemical Structure

CAS No. : 1118567-05-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 160 In-stock
2 mg USD 108 In-stock
5 mg USD 156 In-stock
10 mg USD 228 In-stock
25 mg USD 468 In-stock
50 mg USD 708 In-stock
100 mg USD 1068 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

    Bexagliflozin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2018 Mar 15;152:45-59.

    Effects of NF-κB inhibitor (10 μM MLN120B) is measured on p62 protein in LPS-induced RAW264.7 cells.

    Bexagliflozin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2018 Mar 15;152:45-59.

    PFK2 expression is significantly increased by LPS but is attenuated by Canagliflozin (CAN).

    Bexagliflozin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2018 Mar 15;152:45-59.

    Effects of Dapagliflozin and Empagliflozin on p62 expression in LPS-untreated and LPS-treated RAW264.7 cells.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively. target: SGLT2 IC50: 5.6 μM (SGLT1)/ 2 nM (SGLT2) 1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively. 2) EGT1442 significantly prolonged the median survival of SHRSP rats. 3) EGT1442 dose-dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.

    Clinical Trial
    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.1508 mL 10.7541 mL 21.5082 mL
    5 mM 0.4302 mL 2.1508 mL 4.3016 mL
    10 mM 0.2151 mL 1.0754 mL 2.1508 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    464.94

    Formula

    C₂₄H₂₉ClO₇

    CAS No.

    1118567-05-7

    SMILES

    O[[email protected]]([[email protected]]1O)[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)C2=CC(CC3=CC=C(OCCOC4CC4)C=C3)=C(Cl)C=C2

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Inquiry Information

    Product Name:
    Bexagliflozin
    Cat. No.:
    HY-17604
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