1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Bexagliflozin

Bexagliflozin (Synonyms: EGT1442; EGT0001442; THR-1442)

Cat. No.: HY-17604 Purity: 99.48%
Handling Instructions

Bexagliflozin (EGT1442) is a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor, with IC50s of 2 nM and 5.6 μM for human SGLT2 and SGLT1, respectively. Bexagliflozin can be used for the research of type 2 diabetic.

For research use only. We do not sell to patients.

Bexagliflozin Chemical Structure

Bexagliflozin Chemical Structure

CAS No. : 1118567-05-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 160 In-stock
Estimated Time of Arrival: December 31
2 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 228 In-stock
Estimated Time of Arrival: December 31
25 mg USD 468 In-stock
Estimated Time of Arrival: December 31
50 mg USD 708 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1068 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Bexagliflozin (EGT1442) is a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor, with IC50s of 2 nM and 5.6 μM for human SGLT2 and SGLT1, respectively. Bexagliflozin can be used for the research of type 2 diabetic[1].

IC50 & Target[1]

hSGLT1

5.6 μM (IC50)

hSGLT2

2 nM (IC50)

In Vivo

Bexagliflozin (0.1-10 mg/kg; p.o.) lowers blood glucose levels in a dose-dependent manner after glucose challenge (20%; 2 g/kg;p.o.)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (240-60 g)[1]
Dosage: 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Oral administration
Result: Significantly lower blood glucose in rats and can blunt the normal physiological response to a high dietary glucose load.
Clinical Trial
Molecular Weight

464.94

Formula

C₂₄H₂₉ClO₇

CAS No.

1118567-05-7

SMILES

O[[email protected]]([[email protected]]1O)[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)C2=CC(CC3=CC=C(OCCOC4CC4)C=C3)=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (215.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1508 mL 10.7541 mL 21.5082 mL
5 mM 0.4302 mL 2.1508 mL 4.3016 mL
10 mM 0.2151 mL 1.0754 mL 2.1508 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (6.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (6.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (6.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BexagliflozinEGT1442 EGT0001442 THR-1442EGT 1442EGT-1442EGT0001442EGT 0001442EGT-0001442THR1442THR 1442THR-1442SGLTSodium-dependent glucose cotransporterstype2diabeticmellitusT2DMsodiumglucoseco-transporterSGLT2Inhibitorinhibitorinhibit

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Product Name:
Bexagliflozin
Cat. No.:
HY-17604
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