1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Bexagliflozin

Bexagliflozin (Synonyms: EGT1442; EGT0001442; THR-1442)

Cat. No.: HY-17604 Purity: 99.48%
Handling Instructions

Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively.

For research use only. We do not sell to patients.

Bexagliflozin Chemical Structure

Bexagliflozin Chemical Structure

CAS No. : 1118567-05-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 160 In-stock
Estimated Time of Arrival: December 31
2 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 228 In-stock
Estimated Time of Arrival: December 31
25 mg USD 468 In-stock
Estimated Time of Arrival: December 31
50 mg USD 708 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1068 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively. target: SGLT2 IC50: 5.6 μM (SGLT1)/ 2 nM (SGLT2) 1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively. 2) EGT1442 significantly prolonged the median survival of SHRSP rats. 3) EGT1442 dose-dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.

Clinical Trial
Molecular Weight

464.94

Formula

C₂₄H₂₉ClO₇

CAS No.

1118567-05-7

SMILES

O[[email protected]]([[email protected]]1O)[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)C2=CC(CC3=CC=C(OCCOC4CC4)C=C3)=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (215.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1508 mL 10.7541 mL 21.5082 mL
5 mM 0.4302 mL 2.1508 mL 4.3016 mL
10 mM 0.2151 mL 1.0754 mL 2.1508 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (6.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (6.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (6.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Bexagliflozin
Cat. No.:
HY-17604
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