1. NF-κB
  2. Keap1-Nrf2
  3. Keap1–Nrf2-IN-1

Keap1–Nrf2-IN-1 

Cat. No.: HY-126245
Handling Instructions

Keap1–Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1–Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models.

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Keap1–Nrf2-IN-1 Chemical Structure

Keap1–Nrf2-IN-1 Chemical Structure

CAS No. : 2232112-72-8

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Description

Keap1–Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1–Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1].

IC50 & Target

IC50: 43 nM (Keap1 protein)[1]

Molecular Weight

484.52

Formula

C₂₄H₂₄N₂O₇S

CAS No.

2232112-72-8

SMILES

OC([[email protected]]1N(C2=CC=C(N(CC(O)=O)S(C3=CC=C(OC)C=C3)(=O)=O)C4=C2C=CC=C4)CCC1)=O

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