1. NF-κB
  2. Keap1-Nrf2
  3. Keap1-Nrf2-IN-1

Keap1-Nrf2-IN-1 

Cat. No.: HY-126245 Purity: 98.08%
Handling Instructions

Keap1-Nrf2-IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2-IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models.

For research use only. We do not sell to patients.

Keap1-Nrf2-IN-1 Chemical Structure

Keap1-Nrf2-IN-1 Chemical Structure

CAS No. : 2232112-72-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 480 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Keap1-Nrf2-IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2-IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1].

IC50 & Target

IC50: 43 nM (Keap1 protein)[1]

Molecular Weight

484.52

Formula

C₂₄H₂₄N₂O₇S

CAS No.

2232112-72-8

SMILES

OC([[email protected]]1N(C2=CC=C(N(CC(O)=O)S(C3=CC=C(OC)C=C3)(=O)=O)C4=C2C=CC=C4)CCC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-80°C

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.39 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0639 mL 10.3195 mL 20.6390 mL
5 mM 0.4128 mL 2.0639 mL 4.1278 mL
10 mM 0.2064 mL 1.0319 mL 2.0639 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.55 mg/mL (9.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.08%

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Keywords:

Keap1-Nrf2-IN-1Keap1-Nrf2kelch-likeECH-associatedproteinKeap1Nrf2protein-proteininteractionInhibitorinhibitorinhibit

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Product Name:
Keap1-Nrf2-IN-1
Cat. No.:
HY-126245
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