1. GPCR/G Protein
  2. Adenosine Receptor
  3. KI-7

KI-7 

Cat. No.: HY-131032
Handling Instructions

KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively.

For research use only. We do not sell to patients.

KI-7 Chemical Structure

KI-7 Chemical Structure

CAS No. : 1489263-00-4

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Description

KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2].

In Vitro

KI-7 (1 μM; 5-21 days; mesenchymal stem cells) induces a significant increase in mRNA expression of Runx2 and Osterix[1].
KI-7 (1 μM; 15-21 days) induced a significant increase in cell viability in both differentiation stages[1].
KI-7, as A2B adenosine receptor positive allosteric modulator in MSCs, demonstrating it is able to potentiate the effects of either adenosine and synthetic orthosteric A2B adenosine receptor agonists in mediating osteoblast differentiation in vitro. NECA, BAY 60-6583 and KI-7 induce a strong increase in IL-6 production. KI-7 is able to potentiate the effects of orthosteric agonists in both differentiation stages, even if the effect became significant only at 21 days[1].

Molecular Weight

354.40

Formula

C₂₃H₁₈N₂O₂

CAS No.

1489263-00-4

SMILES

O=C(NC1=CC=CC=C1)C(C2=CN(CC3=CC=CC=C3)C4=C2C=CC=C4)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

KI-7KI7KI 7Adenosine ReceptorP1 receptorRunx2OsterixorthostericallostericMSCpotentiatecAMPaccumulationInhibitorinhibitorinhibit

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