12(S)-HEPE

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.

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  • CAS No.: 116180-17-7
  • 화학식: C₂₀H₃₀O₃
  • 분자량:318.45
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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All Lipoxygenase Isoforms

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All Leukotriene Receptor Isoforms

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