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6-Aminonicotinamide

22 Cited Publications
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Based on 22 publication(s) in Google Scholar

6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells.

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  • Purity: 99.95%
  • CAS No.: 329-89-5
  • 화학식: C6H7N3O
  • 분자량:137.14
  • 보관:

    4°C, protect from light

    * In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

  • 6-Aminonicotinamide Chemical Structure
    6-Aminonicotinamide Chemical Structure
  • Experimental Validation Results for 6-Aminonicotinamide
  • Experimental Validation Results for 6-Aminonicotinamide
  • Experimental Validation Results for 6-Aminonicotinamide
  • Experimental Validation Results for 6-Aminonicotinamide
  • Experimental Validation Results for 6-Aminonicotinamide
  • Experimental Validation Results for 6-Aminonicotinamide
CAS No.: 329-89-5
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  • 6-Aminonicotinamide Chemical Structure
    6-Aminonicotinamide Chemical Structure
    1/16
  • 1/16

    6-Aminonicotinamide purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 7;17(1):8. [Abstract]

    Customer Validation
     Experimental scheme. Wild-type C57BL/6 mice (2 months old) were irradiated with 4.5 Gy X-rays and fed with an AL diet. Mice were then injected intraperitoneally with 10 mg/kg of 6-Aminonicotinamide (6-AN) or saline daily for 7 days post-irradiation, and were continued on an AL diet until 1 month post-irradiation. G6PD enzyme activity (B) and NADPH content (C) in BM cells of AL mice 1 month post-irradiation, analyzed using ELISA.

  • 1/16

    6-Aminonicotinamide purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 7;17(1):8. [Abstract]

    Customer Validation
     Representative images of γH2AX and 53BP1 colocalization in BM cells of AL mice 1 month post-irradiation, determined by immunofluorescent staining. Wild-type C57BL/6 mice (2 months old) were irradiated with 4.5 Gy X-rays and fed with an AL diet. Mice were then injected intraperitoneally with 10 mg/kg of 6-Aminonicotinamide (6-AN) or saline daily for 7 days post-irradiation, and were continued on an AL diet until 1 month post-irradiation.

  • 1/16

    6-Aminonicotinamide purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Jan 7;17(1):8. [Abstract]

    Customer Validation
     Representative FACS Plots of HSCs (Left) and CMPs/GMPs/MEPs (Right) of AL mice 1 month post-irradiation. .Wild-type C57BL/6 mice (2 months old) were irradiated with 4.5 Gy X-rays and fed with an AL diet. Mice were then injected intraperitoneally with 10 mg/kg of 6-Aminonicotinamide (6-AN) or saline daily for 7 days post-irradiation, and were continued on an AL diet until 1 month post-irradiation.

  • 1/16

    6-Aminonicotinamide purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2025 Sep;9(9):1547-1556. [Abstract]

    Customer Validation
     Growth rates of humanized E. coli in LEICA with different compounds. 6-Aminonicotinamide (6AN) (100 μM) completely halted the growth of humanized E. coli for G6PD in LEICA.

  • 1/16

    6-Aminonicotinamide purchased from MedChemExpress. Usage Cited in: Eur J Immunol. 2025 Oct;55(10):e70068. [Abstract]

    Customer Validation
     Alveolar-like macrophages co-stimulated with Poly(I:C) and anti-spike IgA were tested for their dependency on glycolysis, the pentose phosphate pathway, and fatty acid metabolism. Cells preincubated with metabolic inhibitors (6-Aminonicotinamide; 6-AN; 0.1 mM; 24 h) were stimulated and analyzed for their production of IL-6.

  • 1/16

    6-Aminonicotinamide purchased from MedChemExpress. Usage Cited in: Metabolites. 2022 Dec 7;12(12):1227. [Abstract]

    Customer Validation
     6-Aminonicotinamide (6-AN; 1 μM; 0-4 days) significantly promotes the proliferation of LPS853 cells.

  • 6-Aminonicotinamide