AM12
AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.
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- CAS No.: 2387510-84-9
- 화학식: C15H9BrO5
- 분자량:349.13
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 0.28 μM (TRPC5)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.28 μM
Compound: 20; AM12
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Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fura-2 dye based fluorescence assay
Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fura-2 dye based fluorescence assay
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[PMID: 30943030] |
In Vitro
AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A[1].
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it[1].
AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2387510-84-9
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분자량 349.13
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화학식 C15H9BrO5
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SMILES
O=C1C(O)=C(C2=CC=CC=C2Br)OC3=C1C(O)=CC(O)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM12 Related Classifications
HY-128561 Related Classifications
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