Amlodipine mesylate
Based on 15 publication(s) in Google Scholar
Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer.
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- CAS No.: 246852-12-0
- 화학식: C21H29ClN2O8S
- 분자량:504.98
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Amlodipine mesylate
More- Exp Mol Med. 2021 Apr;53(4):572-590. [Abstract]
- J Adv Res. 2024 Aug:62:187-198. [Abstract]
- Sci Adv. 2025 Jan 24;11(4):eadp4765. [Abstract]
- Cell Rep. 2026 May 28;45(6):117471. [Abstract]
- Br J Pharmacol. 2022 May;179(9):2054-2077. [Abstract]
- Cells. 2022 Oct 8;11(19):3156. [Abstract]
- Acta Physiol. 2026 Apr;242(4):e70189. [Abstract]
- J Biochem Mol Toxicol. 2022 Oct 7;e23238. [Abstract]
- Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
- J Chem Thermodyn. 2021, 106495.
- Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
- Nat Prod Commun. 2024 Mar 20.
- Dissolut Technol. 2021 Jun.
- SSRN. 2025 Nov 6.
- medRxiv. 2025 May 21.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Cell Imaging/Staining
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In Vivo Efficacy Study
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Histological Imaging/Staining
All Calcium Channel Isoforms
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Biological Activity
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L-type calcium channel |
Amlodipine mesylate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively[3].
Amlodipine mesylate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells[3].
Amlodipine mesylate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Amlodipine mesylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ATP2B1loxP/loxP mice[4]
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Dosage:5 mg/kg/day
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Administration:Subcutaneously implanted osmotic pump for 2 weeks
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Result:Significantly decreased the blood pressure.
Chemical Information
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CAS No. 246852-12-0
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분자량 504.98
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화학식 C21H29ClN2O8S
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SMILES
O=S(C)(O)=O.O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Exp Mol Med
Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis. [Abstract]2021 Apr;53(4):572-590. PMID: 33811247
Amlodipine mesylate purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2021 Apr;53(4):572-590. [Abstract]
Rat GMCs pretreated with the calcium channel blocker Amlodipine (10μM), inhibitors of PKC (Go6983; 10μM), c-Raf (AZ628, 10μM) and MEK1/2 (U0126, 10μM) for 30min were stimulated with sublytic C5b-9 for 4 0min or 2h. The intracellular calcium was determined by Fluo-4 AM. The results showed that Amlodipine effectively blocked the rise in intracellular calcium levels in rat GMCs induced by 40 min of sublytic C5b-9 stimulation.
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J Adv Res
Calcium Influx: An Essential Process by which α-Synuclein Regulates Morphology of Erythrocytes. [Abstract]2024 Aug:62:187-198. PMID: 37714326 -
Sci Adv
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function. [Abstract]2025 Jan 24;11(4):eadp4765. PMID: 39841844 -
Cell Rep
2026 May 28;45(6):117471. PMID: 42213774 -
Br J Pharmacol
Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota. [Abstract]2022 May;179(9):2054-2077. PMID: 34862599 -
Cells
Calcium-Related Genes Predicting Outcomes and Serving as Therapeutic Targets in Endometrial Cancer. [Abstract]2022 Oct 8;11(19):3156. PMID: 36231119 -
Acta Physiol
Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence-The Protective Effect of Valsartan. [Abstract]2026 Apr;242(4):e70189. PMID: 41814130 -
J Biochem Mol Toxicol
An in vivo and in vitro model on the protective effect of cilnidipine on contrast-induced nephropathy via regulation of apoptosis and CaMKⅡ/mPTP pathway. [Abstract]2022 Oct 7;e23238. PMID: 36207783 -
Food Chem Toxicol
Coexposure to fluoride and sulfur dioxide aggravates enamel mineralization disorders in mice by disrupting calcium homeostasis-mediated endoplasmic reticulum stress. [Abstract]2025 Apr:198:115317. PMID: 39938609
Amlodipine mesylate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
A CCK-8 assay was used to detect the effect of AMs on the proliferation of Ishikawa cells. The results showed that the half-maximal inhibitory concentration (IC50) of Amlodipine (AM) against Ishikawa cells (at 72 h) was 12.36 μM.
Amlodipine mesylate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
Cell apoptosis rate was detected by flow cytometry using Annexin-V/PI staining. The results showed that the apoptotic rate of the Amlodipine (AM) (15 μM; 12 h)-treated Ishikawa cells was 16.8%, which was 2.16-fold higher than that in cells treated with DMSO.
Amlodipine mesylate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
EdU staining showing the effect of Amlodipine (AM) (15 μM; 48 h) on Ishikawa cells. The EdU staining assay revealed that the EdU-positive rate of the AM-treated Ishikawa cells was significantly reduced compared with that of the control group.
Amlodipine mesylate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks) inhibited tumor growth in a dose-dependent manner in BALB/c nude mice bearing subcutaneous xenografts established from Ishikawa cells.
Amlodipine mesylate purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2025 Apr:198:115317. [Abstract]
H&E and PCNA staining of sections from mice treated with Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks).
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Biochem Biophys Res Commun
Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]2020 Feb 19;522(4):862-868. PMID: 31806372 -
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순도&문서
References
[1]. Kishen G. Bulsara, et al. Amlodipine.
[2]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [Content Brief]
[3]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. [Content Brief]
[4]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. [Content Brief]
Calculators
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Amlodipine mesylate Related Classifications
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