Anti-Mouse CD3 Antibody (17A2)
Based on 1 publication(s) in Google Scholar
Anti-Mouse CD3 Antibody (17A2) is an anti-mouse CD3 IgG2b antibody inhibitor derived from the host Rat. Anti-Mouse CD3 Antibody (17A2) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic T cells. Anti-Mouse CD3 Antibody (17A2) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models.
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- Purity: 99%
- 분자량:150 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Anti-Mouse CD3 Antibody (17A2)
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Biological Activity
Rat IgG2b kappa
Mouse
Anti-Mouse CD3 Antibody (17A2) (1-1000 ng/mL, 96 h) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic pan-T cells[1].
Anti-Mouse CD3 Antibody (17A2) (1 μg/mL, 48 h) significantly elevates mRNA levels for these Th1 and IL-17 genes in splenic T cells[1].
Anti-Mouse CD3 Antibody (17A2) (48 h) significantly enhances IRBP (interphotoreceptor retinoid-binding protein)-stimulated production of IFN-γ in ocular cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Splenic T cells
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Concentration:1 μg/mL
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Incubation Time:48 h
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Result:Increased the levels of IL-1α, IFN-γ, T-bet and IL-17 and decreased the levels of IL-10 and Foxp3.
Anti-Mouse CD3 Antibody (17A2) (200 or 400 μg, i.v., 20 h after irradiation and 4 h before transplantation) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice[2]
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Dosage:100 and 400 μg
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Administration:Intravenously injection
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Result:Significantly reduced T cells.
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Animal Model:Graft-versus-host disease (GVHD) mice models[2]
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Dosage:200 and 400 μg
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Administration:Intravenously injection, 20 h after irradiation and 4 h before spleen cells and bone marrow cells transplantation
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Result:Suppressed GVHD mortality by about 50% on day 100 posttransplantation and 20% to 40% on day 200.
Prolonged antibody treatment by further injections of 200 μg on days 3,6, and 9 after transplantation.
led to long-term survivors with 90% to 97% chimerism on days 50 and 100.
Reduced CD4+ cells to about 50% and CD8+ cells to 10% after 50 days.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
in vitro T cell stimulation/activation
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Immobilized CD3E-CD3G Heterodimer Protein, Mouse (HEK293, Fc, HY-P75414) can bind Anti-Mouse CD3 Antibody (17A2). The EC50 for this effect is 31.62 ng/mL.
Chemical Information
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Appearance Liquid
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분자량 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD3 Antibody (17A2)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Neuropharmacology
Enhanced interleukin-16-CD4 signaling in CD3 T cell mediates neuropathic pain via activating astrocytes in female mice. [Abstract]2024 Nov 15:259:110115. PMID: 39137872
순도&문서
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Sugita S, et al. Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody. Arthritis Res Ther. 2017 Jul 25;19(1):176. [Content Brief]
[2]. Mysliwietz J, et al. Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient. Blood. 1992 Nov 15;80(10):2661-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD3 Antibody (17A2) Related Classifications
HY-P99124 Related Classifications
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