2. Immunology/Inflammation
  3. CD28
  4. Anti-Mouse CD28 Antibody (37.51)

Anti-Mouse CD28 Antibody (37.51) 

Cat. No.: HY-P99123 Pureza: 95.00%
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Anti-Mouse CD28 Antibody (37.51) is an agonistic agonistic CD28-specific antibody derived from the host Syrian Hamster. Anti-Mouse CD28 Antibody (37.51) partially prevents lethal graft-versus-hostdisease (GVHD) by selective depletion of alloreactive T cells in mice.

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2 Publications Citing Use of MCE Anti-Mouse CD28 Antibody (37.51)

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Descripciòn

Anti-Mouse CD28 Antibody (37.51) is an agonistic agonistic CD28-specific antibody derived from the host Syrian Hamster. Anti-Mouse CD28 Antibody (37.51) partially prevents lethal graft-versus-hostdisease (GVHD) by selective depletion of alloreactive T cells in mice[1].

Isotype

Syrian hamster IgG2
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

CD28
In Vivo

Anti-Mouse CD28 Antibody (37.51) (100 μg once or 20 μg every other day for 8 times, i.p.) prevents graft-versus-host disease (GVHD) lethality in myeloablative mice models of T-cell–replete marrow transplantation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lethally irradiated (1200 cGy) B10.BR mice were given transplants of 15 x 106 T cell–depleted marrow cells plus 25 x 106 splenocytes from B6 donors[1]
Dosage: 20 μg and 100 μg for a single dose, 20 μg every other day for 8 times
Administration: Intraperitoneally injection
Result: Delayed the onset of GVHD and improved survival after a single 20-μg dose.
Protected 60% of mice from lethal acute GVHD after a single 100-μg dose.
Resulted of 20 μg administered every other day for 8 days similar to those with a single 100-μg dose.
Decreased donor CD4+ cells and CD8+ cells.
Reduced numbers of T- and B- cells in the spleen.
Gene ID

12487  [NCBI]

Accession
Application

in vitro T cell stimulation/activation; in vivo CD28 blockade
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD28 Antibody (37.51)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized Mouse CD28 protein can bind Anti-Mouse CD28 Antibody (37.51). The EC50 for this effect is 29.05 ng/mL.
Pureza y Documentación

Purity: 95.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)
Referencias
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Anti-Mouse CD28 Antibody (37.51) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD28 Antibody (37.51)CD28T cellsGVHDInhibitorinhibitorinhibit

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Nombre del producto:
Anti-Mouse CD28 Antibody (37.51)
Cat. No.:
HY-P99123
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MCE Japan Authorized Agent:

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