Anti-Mouse IFN gamma Antibody (H22)
Based on 2 publication(s) in Google Scholar
Anti-Mouse IFN gamma Antibody (H22) is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IFN gamma Antibody (H22) abrogates specific binding of I25II-rIFN-γ to macrophages. Anti-Mouse IFN gamma Antibody (H22) inhibits macrophage-activating factor (MAF) (ID50 = 56 ng). Anti-Mouse IFN gamma Antibody (H22) inhibits IFN-gamma dependent antiviral activity (ID50 = 2 ng). Anti-Mouse IFN gamma Antibody (H22) neutralizes IFNγ in mice. Anti-Mouse IFN gamma Antibody (H22) can be used for the researches of inflammation and infection, such as arthritis.
For research use only. We do not sell to patients.
- Purity : ≥95.0%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Anti-Mouse IFN gamma Antibody (H22)
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Biological Activity
Description
Isotype
Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
IFN gamma
In Vitro
Anti-Mouse IFN gamma Antibody (H22) (1 h) inhibits both macrophage-activating factor (MAF) and antiviral activities with ID50 of 56 ng and 2 ng[4]. Anti-Mouse IFN gamma Antibody (H22) (50 ng, 2 h) abrogates specific binding of I25II-rIFN-γ to macrophages[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Mouse IFN gamma Antibody (H22) (250 μg, i.p., at days 0, 6, 13 21, 28, 35 and 42 for 7 times) highly increases the number of limbs affected by arthritis in collagen-induced arthritis mice models[2].
Anti-Mouse IFN gamma Antibody (H22) (100 μg, i.p., once weekly beginning 5 h before cell transfer) completely ablates the protective effect of Lyt-2+ immune T cells against toxoplasmosis in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Collagen-induced arthritis mice models (DBA/I, male, 10-12 weeks)[2]
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Dosage:250 μg
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Administration:Intraperitoneally injection, at days 0, 6,13, 20, 21, 28, 35 and 42
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Result:Highly increased the number of limbs affected by arthritis.
Increased clinical scores at day 45.
Increased limb involvement consistently.
Did not influence the number of mice which developed arthritis, or the time of onset of disease.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
ELISA, FACS, Functional assay, Research in vivo
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IFN gamma Antibody (H22)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditis. [Abstract]2025 Feb 10;10(1):59. PMID: 39924580 -
Sci Immunol
2026 May;11(119):eadz0348. PMID: 42066062
Purity & Documentation
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Data Sheet (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Slaney CY, et al. Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting. Clin Cancer Res. 2017 May 15;23(10):2478-2490. [Content Brief]
[2]. Williams RO, et al. Increased limb involvement in murine collagen-induced arthritis following treatment with anti-interferon-gamma. Clin Exp Immunol. 1993 May;92(2):323-7. [Content Brief]
[3]. uzuki Y, et al. The effect of anti-IFN-gamma antibody on the protective effect of Lyt-2+ immune T cells against toxoplasmosis in mice. J Immunol. 1990 Mar 1;144(5):1954-6. [Content Brief]
[4]. Schreiber RD, et al. Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity. J Immunol. 1985 Mar;134(3):1609-18. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IFN gamma Antibody (H22) Related Classifications
HY-P99136 Related Classifications
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