Cd28 - CD28 antigen Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12487

About Cd28

Chromosome 1: 60,755,959-60,812,518 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 132 orthologues, 1 paralogue and is associated with 47 phenotypes. Biased expression in thymus adult (RPKM 17.9), spleen adult (RPKM 1.8) and 1 other tissue.

Summary

Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd28 Products (2)

mRNA Protein Name
NM_007642.4 NP_031668.3 T-cell-specific surface glycoprotein CD28 precursor
NM_007642.4 NP_031668.3 T-cell-specific surface glycoprotein CD28 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21245484 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
8125140 MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
9368605 MGI
acts upstream of or within T cell costimulation IDA
IDA: Inferred from direct assay
8125140 MGI
acts upstream of or within T cell costimulation IGI
IGI: Inferred from genetic interaction
23793062 MGI
acts upstream of or within T cell costimulation IMP
IMP: Inferred from mutant phenotype
7688139 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
12925852 MGI
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
7688139 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23793062 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10429671 MGI
acts upstream of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
7688139 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: Inferred from mutant phenotype
10429671 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
23589618 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
8125140 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
9368605 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
12867038 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
7688139 MGI
acts upstream of or within positive regulation of inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
10791997 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
7688139 MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes IMP
IMP: Inferred from mutant phenotype
7688139 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
23589618 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16809611 MGI
acts upstream of or within regulation of regulatory T cell differentiation IGI
IGI: Inferred from genetic interaction
21245484 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16809611 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7790813 MGI
located in external side of plasma membrane IMP
IMP: Inferred from mutant phenotype
7688139 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
23793062 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd28 Protein Structure

Ig

Ig: cl11960 (21 - 137)

Ig

Ig: cd00096 (36 - 40)

Ig

Ig: cd00096 (52 - 56)

Ig

Ig: cd00096 (95 - 99)

Ig

Ig: cd00096 (109 - 114)

Ig

Ig: cd00096 (127 - 131)

  • 0
  • 100
  • 200
  • 218 a.a.
Protein Preferred Names Protein Names

T-cell-specific surface glycoprotein CD28

Recombinant Cd28 Proteins

Cat. No. Product Name Accession Purity
HY-P70614 CD28 Protein, Mouse (HEK293, Fc-His) P31041 (N20-K149) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74311 CD28 Protein, Mouse (Biotinylated , HEK293, His) P31041 (N20-K149) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P1698B Reltecimod TFA Chemical 99.78% Phase 3
Inhibitory Antibodies (14)
Cat. No. Product Name Effect
Purity Phase
HY-P9986 Tiragolumab Inhibitor 99.04% Phase 3
HY-P99293 Galiximab Inhibitor 99.23% Phase 3
HY-P99961 Tifcemalimab Inhibitor 96.02% Phase 3
HY-P9975 Theralizumab Agonist 99.46% Phase 2
HY-P99302 Lulizumab Inhibitor ≥95.0% Phase 2
HY-P990587 FR104 Inhibitor 97.26% Phase 2
HY-P99420 Acazicolcept Antagonist 99.27% Phase 2
HY-P990773 Venanprubart Inhibitor 98.00% Phase 2
HY-P99431 KY-1044 99.51% Phase 2
HY-P99893 Rozibafusp alfa Inhibitor 96.98% Phase 2
HY-P990079 Renvistobart Inhibitor 99.95% Phase 2
HY-P990752 Nezastomig / Phase 2
HY-P991183 SAR-442257 Ligand ≥99.0% Phase 1
HY-P991176 RG-6333 Agonist 98.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122822 GSK699 Activator 98.80% Unkown
HY-P1698 Reltecimod Antagonist 98.62% Yes
HY-102090 B7/CD28 interaction inhibitor 1 99.81% Unkown
HY-100891 CD80-IN-3 98.02% Unkown
HY-19486 UR-1505 Inhibitor 99.97% Unkown
HY-162810 ICOS-IN-1 / Unkown
HY-169819 Calcium influx inducer compound 634 Activator / Unkown
HY-N10446 Maydispenoid B / Unkown
HY-179648 CD28-IN-2 Inhibitor / Unkown
HY-175780 CD28-IN-1 Inhibitor / Unkown
HY-176265 DDS5 Inhibitor / Unkown
HY-184441 CD28-IN-4 Inhibitor / Unkown
HY-168384 M04 / Unkown
HY-181507 CD28-IN-3 Inhibitor / Unkown
HY-N10445 Maydispenoid A / Unkown
Inhibitory Antibodies (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99123 Anti-Mouse CD28 Antibody (37.51) 95.00% Unkown
HY-P990865 Anti-CD28 Antibody (9.3) Inhibitor 99% Unkown
HY-P990136 Anti-Monkey/Human CD28 Antibody (CD28.2) Inhibitor 95.00% Unkown
HY-P991907 Anti-CD80 Antibody (TKMF5) 96.92% Unkown
HY-P990298 Anti-Mouse BTLA/CD272 Antibody (6A6) Inhibitor 95.00% Unkown
HY-P992125 Radanstobart Inhibitor 99.12% Unkown
HY-P991038 Zadoprubart 99% Unkown
HY-P990237 Anti-Mouse ICOS Antibody (7E.17G9) Inhibitor 98% Unkown
HY-P990128 Anti-Rat CD80/B7-1 Antibody (3H5) Inhibitor / Unkown
HY-P992182 ANB032 Agonist / Unkown
HY-P992196 Anti-Canine CD28 Antibody (1C6) Inhibitor / Unkown
HY-P991835 Anti-Mouse BTLA/CD272 Antibody (PJ196) Inhibitor / Unkown
HY-P991833 Anti-Mouse BTLA/CD272 Antibody (PK18.6) Inhibitor / Unkown
HY-P990803 Anti-Mouse CD28 Antibody (PV-1) Inhibitor 96.63% Unkown
HY-P99123A Anti-Mouse CD28 (LALA-PG) Antibody (D665) Inhibitor / Unkown
HY-P990793 Anti-Mouse CD28 Antibody (D665) Inhibitor / Unkown
HY-P990137 Anti-Rat CD28 Antibody (JJ319) Inhibitor / Unkown
HY-P990819 Anti-Rat CD28 Antibody (JJ316) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd28 NCBI NCBI:940