Cd28 - CD28 antigen Gene

Mus musculus

Gene ID: 12487 | Gene type: protein coding

About Cd28

Chromosome 1: 60,755,959-60,812,518 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 132 orthologues, 1 paralogue and is associated with 47 phenotypes. Biased expression in thymus adult (RPKM 17.9), spleen adult (RPKM 1.8) and 1 other tissue.

Summary

Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd28 Products(1)

mRNA	Protein	Name
NM_007642.4	NP_031668.3	T-cell-specific surface glycoprotein CD28 precursor

Cd28 Protein Structure

0
100
200
218 a.a.

Protein Preferred Names

Protein Names

T-cell-specific surface glycoprotein CD28

Recombinant Cd28 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70614	CD28 Protein, Mouse (130a.a, HEK293, Fc-His)	P31041 (N20-K149)	≥95%
HY-P73496	CD28 Protein, Mouse (149a.a, HEK293, His-Fc)	P31041 (M1-K149)	≥95%
HY-P74311	CD28 Protein, Mouse (Biotinylated , HEK293, His)	P31041 (N20-K149)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1698	Reltecimod	Antagonist	/	Phase 3

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99961	Tifcemalimab	Inhibitor	95.00%	Phase 3
HY-P99293	Galiximab	Inhibitor	99.23%	Phase 3
HY-P99302	Lulizumab	Inhibitor	≥95.0%	Phase 2
HY-P99420	Acazicolcept	Antagonist	99.27%	Phase 2
HY-P99717	Lulizumab pegol	Antagonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-102090	B7/CD28 interaction inhibitor 1		99.47%	Unkown
HY-P1698B	Reltecimod TFA	Chemical	99.78%	Unkown
HY-N10445	Maydispenoid A		/	Unkown
HY-N10446	Maydispenoid B		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9975	Theralizumab	Agonist	97.21%	Unkown
HY-P99123	Anti-Mouse CD28 Antibody (37.51)		≥95.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd28	NCBI	NCBI:940
Canis familiaris	Cd28	NCBI	NCBI:403646
Macaca fascicularis	Cd28	NCBI	NCBI:102146670
Rattus norvegicus	Cd28	NCBI	NCBI:25660
Macaca mulatta	Cd28	NCBI	NCBI:705313

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