Maydispenoid B
Maydispenoid B is a potent immunosuppressor. Maydispenoid B can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.
For research use only. We do not sell to patients.
- CAS No.: 3024647-69-3
- Formula: C25H34O4
- Molecular Weight:398.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
10 μM
Compound: 2; DRB
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 33074690] |
In Vitro
Maydispenoid B (compound 3) exhibits potential inhibitory activity in anti-CD3/anti-CD28 monoclonal antibodies (mAbs) stimulated murine splenocytes proliferation, with an IC50 value of 9.38 μM, respectively[1].
Maydispenoid B suppresses the murine splenocytes proliferation activated by lipopolysaccharide (LPS), with an IC50 value of 16.82 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3024647-69-3
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Molecular Weight 398.54
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Formula C25H34O4
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SMILES
CC1=CC(/C2=C(C(C[C@]3([C@@]4([C@@H](C)C[C@H](/C=C(C)/C)O4)CC[C@@]3(C[C@]12[H])C)[H])=O)\CO)=O
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Structure Classification
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Initial Source
Bipolaris maydis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Maydispenoid B Related Classifications
HY-N10446 Related Classifications
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