SAR443216
SAR443216 is a trispecific antibody targeting HER2/CD3/CD28. SAR443216 binds to the tumor-associated antigen HER2 and the T cell receptor complex component CD3; through CD28 costimulatory signaling, SAR443216 activates the IL-2/NF-κB pathway and upregulates Bcl-xL, thereby promoting T cell activation and proliferation, enhancing T cell-dependent cytotoxicity, and inducing the release of cytokines and granzyme B. SAR443216 exhibits antitumor activity in HER2-positive models and can be used for research on HER2-positive solid tumors.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
Description
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HER2 |
IL-2 |
NF-κB |
Bcl-xL |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[SAR443216]
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SAR443216 Related Classifications
HY-P992588 Related Classifications
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