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B7/CD28 interaction inhibitor 1 

Cat. No.: HY-102090 Purity: 99.68%
Handling Instructions

B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM.

For research use only. We do not sell to patients.

B7/CD28 interaction inhibitor 1 Chemical Structure

B7/CD28 interaction inhibitor 1 Chemical Structure

CAS No. : 635324-72-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 259 In-stock
Estimated Time of Arrival: December 31
5 mg USD 235 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
25 mg USD 700 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1].

IC50 & Target

IC50: 50 nM (B7.1-CD28 interaction)[1]

In Vitro

Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

427.35

Formula

C₂₁H₁₃F₄N₅O

CAS No.

635324-72-0

SMILES

O=C1N(C2=CC=C(F)C=C2)NC3=C4C(N(C)N=C4)=NC(C5=CC=CC(C(F)(F)F)=C5)=C31

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

B7/CD28 interaction inhibitor 1OthersT-cellresponsesB7.1CD28CTLA-4immunosuppressionantibodiesInhibitorinhibitorinhibit

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B7/CD28 interaction inhibitor 1
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HY-102090
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