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B7/CD28 interaction inhibitor 1 

Cat. No.: HY-102090
Handling Instructions

B7/CD28 interaction inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM.

For research use only. We do not sell to patients.

B7/CD28 interaction inhibitor 1 Chemical Structure

B7/CD28 interaction inhibitor 1 Chemical Structure

CAS No. : 635324-72-0

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B7/CD28 interaction inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1].

IC50 & Target

IC50: 50 nM (B7.1-CD28 interaction)[1]

In Vitro

Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere.


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B7/CD28 interaction inhibitor 1OthersT-cellresponsesB7.1CD28CTLA-4immunosuppressionantibodiesInhibitorinhibitorinhibit

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