Anti-Monkey/Human CD28 Antibody (CD28.2)
Based on 1 Customer Validation
Anti-Monkey/Human CD28 Antibody (CD28.2) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to monkey/human CD28. Anti-Monkey/Human CD28 Antibody (CD28.2) can block CD28 signaling. Anti-Monkey/Human CD28 Antibody (CD28.2) can be used for the research of immunology.
For research use only. We do not sell to patients.
- Purity: 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mouse IgG1 kappa
Mouse
CD28
Anti-Monkey/Human CD28 Antibody (CD28.2) (10 μg/mL, 15 mins) reduces YT2C2 cells-mediated lysis of the B7-positive JY target cells[2].
Anti-Monkey/Human CD28 Antibody (CD28.2) (2 μg/mL, 6 h) stimulates Jurkat T cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD/SCID mice were transferred with human peripheral blood mononuclear cells[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneally injection, 1 week after transfer
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Result:Resulted in the release of IL-6 and IL-8.
940/705313 [NCBI]
P10747-1 / Q0PDN3 / Q0PDN4
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vitro T cell stimulation/activation; Immunoprecipitation; Flow cytometry; Immunohistochemistry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Monkey/Human CD28 Antibody (CD28.2)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Poirier N, et al. Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent Fab' antibody. Am J Transplant. 2012 Oct;12(10):2630-40. [Content Brief]
[2]. Roger R, et al. CD28-mediated cytotoxicity of YT natural killer cells on B7-positive targets induces rapid necrotic death independent of granule exocytosis. Cell Immunol. 1996 Feb 25;168(1):24-32. [Content Brief]
[3]. Oh YM, et al. Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2. Nat Commun. 2015 Oct 28;6:8698. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Monkey/Human CD28 Antibody (CD28.2) Related Classifications
HY-P990136 Related Classifications
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