Rozibafusp alfa
Based on 1 Customer Validation
Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Rozibafusp alfa can be used for the research of systemic lupus erythematosus and other autoimmune diseases.
For research use only. We do not sell to patients.
- Purity: 96.98%
- CAS No.: 2143449-47-0
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG2 kappa
Human
| Cynomolgus Monkeys IV 10 mg/kg |
Cynomolgus Monkeys SC 10 mg/kg |
|
| Cmax (μg/mL) | 264 | 112 |
| Tmax (hr) | 72 | |
| AUC0-inf (μg•hr/mL) | 26100 | 23800 |
| MRT0-inf (hr) | 138 | 144 |
| CL (mL/hr/kg) | 0.388 | 0.427 |
| Vss (mL/kg) | 52.1 | |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG2 kappa
ELISA, FACS, Functional assay
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Immobilized B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78075) can bind Rozibafusp alfa. The EC50 for this effect is 12.53 ng/mL.
Chemical Information
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CAS No. 2143449-47-0
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Rozibafusp alfa]
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Synonyms
AMG-570
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)