country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-174325

Copy Link Print Information

Antimalarial agent 50

Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2384242-67-3
화학식: C₂₄H₁₈N₄OS
분자량:410.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antimalarial agent 50 Chemical Structure

CAS No.: 2384242-67-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Parasite Isoforms :

In Vivo

Antimalarial agent 50 (Compound 3a) (200-800 μg/kg; i.p.; once daily; for 4 days) can dose dependently reduce parasitic infections in a mouse model of malaria parasite infection and exhibits anti-inflammatory and antioxidant potential^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

P. berghei NK 65 strain injected male Balb/c mice model (6-8 weeks)^[1].
Dosage:

200-800 μg/kg, Positive control group Chloroquine (HY-17589A)
Administration:

Intraperitoneal injection (i.p.)
Result:

Showed the best anti parasitemia effect at 800 µg/kg with the inhibition rate of 83.6 %.
Restored RBCs similar to the vehicle control group.
Improved the condition of the ruffled fur and anxiety.
Significantly reversed RBCs, Hb, PCV, MCV, MCH, MCHC and platelets of infected mice.
Significantly reduced the concentration of AST, ALP, ALT and bilirubin, creatinine, uric acid and improved the pathological structure of the liver and spleen.
Improved the concentration of GSH, GST and CAT and reduced the concentration of NO and MDA.
Restored blood sugar levels in the infected mice.
Reduced the level of inflammatory factors NF-κB, IL-6, IFN-γ and decreased the level of the TNF-α, iNOS, IL-1β

Chemical Information

CAS No. 2384242-67-3
분자량 410.49
화학식 C₂₄H₁₈N₄OS
SMILES

O=C(N1N=C(C2=CC=CC=C2)C=C1C3=CC=CC=C3)CSC4=NC5=CC=CC=C5N4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hamid A, et al. Antiplasmodial effect of benzimidazole-pyrazole derivative against Plasmodium berghei infection in mice model. Bioorg Chem. 2025 May 28;163:108634. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Antimalarial agent 50

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antimalarial agent 50 Related Classifications

HY-174325 Related Classifications