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Cat. No.: HY-163003

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Antitrypanosomal agent 19

Antitrypanosomal agent 19 (compound 10) is an orally available antitrypanosomal agent. Antitrypanosomal agent 19 effectively inhibits the growth of trypanosomatids T. b. brucei, T. b. gambiense and T. b. rhodesiense, mitigating the Human trypanosomiasis (HAT)-induced acute infectious toxicity in mice.

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화학식: C₁₀H₁₁N₃O₄S
분자량:269.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antitrypanosomal agent 19 Chemical Structure

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가격

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Trypanosome^[1]

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	>75 μM Compound: 10	Cytotoxicity against human HepG2 cells assessed as cell growth measured after 72 hrs mby MTT assay Cytotoxicity against human HepG2 cells assessed as cell growth measured after 72 hrs mby MTT assay	[PMID: 37984297]

Chemical Information

분자량 269.28
화학식 C₁₀H₁₁N₃O₄S
SMILES

O=C(C1=CC=C([N+]([O-])=O)S1)NC/C=C/C(NC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ajayi O et al. Discovery of an orally active nitrothiophene-based antitrypanosomal agent[J]. European Journal of Medicinal Chemistry, 2023: 115954.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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Antitrypanosomal agent 19

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antitrypanosomal agent 19 Related Classifications

HY-163003 Related Classifications