NOX1 - NADPH oxidase 1 Gene

Also Known as MOX1; NOH1; NOH-1; GP91-2; NOH-1L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27035

About NOX1

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,843,324-100,874,359 (from NCBI)

This gene has 5 transcripts (splice variants), 126 orthologues and 6 paralogues. Restricted expression toward colon (RPKM 30.7).

Summary

This gene encodes a member of the NADPH Oxidase family of Enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

NOX1 Products (5)

mRNA	Protein	Name
NM_007052.5	NP_008983.2	NADPH oxidase 1 isoform 1
NM_001271815.2	NP_001258744.1	NADPH oxidase 1 isoform 3
NM_013955.3	NP_039249.1	NADPH oxidase 1 isoform 2
XM_017029407.3	XP_016884896.1	NADPH oxidase 1 isoform X1
NM_013954.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16329988	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	16636067	GOA
enables superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	14617635	GOA
enables superoxide-generating NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	18023288	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	11805326	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18023288	GOA
involved in hydrogen peroxide metabolic process	IDA IDA: Inferred from direct assay	11331784	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10485709	GOA
involved in positive regulation of integrin biosynthetic process	IMP IMP: Inferred from mutant phenotype	18023288	GOA
involved in positive regulation of vascular endothelial growth factor production	IEP IEP: Inferred from expression pattern	11805326	GOA
involved in superoxide anion generation	IDA IDA: Inferred from direct assay	10485709	GOA
involved in superoxide anion generation	IMP IMP: Inferred from mutant phenotype	18023288	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NADPH oxidase complex	IDA IDA: Inferred from direct assay	16636067	GOA
located in early endosome	IDA IDA: Inferred from direct assay	17673675	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14617635	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOX1 Protein Structure

Ferric_reduct

FAD_binding_8

NAD_binding_6

0
100
200
300
400
500
564 a.a.

Protein Preferred Names	Protein Names
NADPH oxidase 1	NADH/NADPH mitogenic oxidase subunit P65-MOX NADPH oxidase homolog-1 mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating) mitogenic oxidase 1

NOX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOX1	Q9Y5S8	TBXA2R	Homo sapiens	Q0VAB0	Y2H Array	32296183
Intra	NOX1	Q9Y5S8	TBXA2R	Homo sapiens	Q0VAB0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

NOX1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P811147	NOX1 Antibody	WB, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Granulomatous Disease, Chronic, Autosomal Recessive, 1	Chronic Granulomatous Disease Due To Deficiency Of Ncf-1 CGD1 Ncf1 Deficiency Soluble Oxidase Component Ii Deficiency Soc2 Deficiency P47-Phox Deficiency Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I Deficiency Of Neutrophil Cytosol Factor 1 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I Cgd, Autosomal Recessive Cytochrome B-Positive, Type I Granulomatous Disease, Chronic, Due To Ncf1 Deficiency Neutrophil Cytosol Factor 1 Deficiency Chronic Granulomatous Disease 1, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 1 Cdg1 Deficiency Of Ncf1 Deficiency Of P47-Phox Deficiency Of Soc2 Deficiency Of Soluble Oxidase Component Ii Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I Chronic Granulomatous Disease Due To Ncf1 Deficiency
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Diabetes Mellitus	Diabetes
Diabetic Angiopathy	Diabetic Angiopathies Diabetic Peripheral Angiopathy Diabetic Vascular Disorder
Ileocolitis	Iieocolitis
Granulomatous Disease, Chronic, Autosomal Recessive, 4	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative Cyba Deficiency CGD4 Cgd Due To Deficiency Of The Alpha Subunit Of Cytochrome B Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Negative Cgd, Autosomal Recessive Cytochrome B-Negative Chronic Granulomatous Disease 4, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 4 Autosomal Recessive Cytochrome B-Negative Cgd Chronic Granulomatous Disease Due To Deficiency Of Cyba Cgd Due To Deficiency Of Alpha Subunit Of Cytochrome B Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Negative Granulomatous Disease, Chronic, Cytochrome-B-Negative, Autosomal Recessive
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Phagocyte Bactericidal Dysfunction	Phagocytic Dysfunction
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-B0807A	Prochlorperazine dimaleate	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Phase
HY-12298	Setanaxib	Inhibitor	99.81%	Phase 2
HY-120801A	APX-115 free base	Inhibitor	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-12805	ML171	Inhibitor	99.53%	Unkown
HY-120801	APX-115	Inhibitor	99.90%	Unkown
HY-101499	GKT136901	Inhibitor	99.33%	Unkown
HY-P1435	NoxA1ds	Inhibitor	95.34%	Unkown
HY-126195	Fluoflavine	Inhibitor	98.47%	Unkown
HY-105946	Hidrosmin	Inhibitor	95.34%	Unkown
HY-P1435A	NoxA1ds TFA	Inhibitor	/	Unkown
HY-174818	NOX5-IN-2	Inhibitor	/	Unkown
HY-174817	NOX5-IN-1	Inhibitor	/	Unkown
HY-148936	GLX481372	Inhibitor	/	Unkown
HY-183101	AMPAR modulator-12	Inhibitor	/	Unkown
HY-124487	GK-136901	Inhibitor	/	Unkown
HY-128004	ML171 analog 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NOX1	VGNC	VGNC:75374
Rattus norvegicus	NOX1	RGD	RGD:620598
Mus musculus	NOX1	MGD	MGI:2450016
Bos taurus	NOX1	VGNC	VGNC:32182
Felis catus	NOX1	VGNC	VGNC:68522
Canis familiaris	NOX1	VGNC	VGNC:43903
Others	NOX1	NCBI