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Cat. No.: HY-176741

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MAPK ligand 1

MAPK ligand 1 is an apoptosis inducer and Bcl-xL/MAPK ligand that can be used to synthesize the Bcl-xL-targeted PROTAC degrader (HY-176740). MAPK ligand 1 triggers apoptosis through the mitochondrial pathway, MAPK pathway, reduction of mitochondrial membrane potential and elevation of reactive oxygen species levels. MAPK ligand 1 inhibits colony formation and migration of cancer cells, as well as angiogenesis of endothelial cells. MAPK ligand 1 can be used in the research of hepatocellular carcinoma.

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CAS No.: 2566503-77-1
화학식: C₂₀H₁₃NO₃
분자량:315.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAPK ligand 1 Chemical Structure

CAS No.: 2566503-77-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Bcl-xL

All Bcl-2 Family Isoforms :

Chemical Information

CAS No. 2566503-77-1
분자량 315.32
화학식 C₂₀H₁₃NO₃
SMILES

OC(C1=CC2=C(NC(C3=CC=CC4=C3C=CC=C4)=CC2=O)C=C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Sun G, et al. Protac synthesized on the basis of azaflavonoid derivatives possesses favorable anti-hepatocellular carcinoma activity. Bioorganic chemistry. 2025 Aug;163:108687. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- IC₅₀ & Target
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MAPK ligand 1

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

MAPK ligand 1 Related Classifications

HY-176741 Related Classifications