Linifanib (Synonyms: ABT-869; AL-39324)

Name: Linifanib
Brand: MedChemExpress
SKU: HY-50751G
Rating: 4.5 (1 reviews)

Cat. No.: HY-50751G: Data Sheet
SDS
Handling Instructions
FAQs
Technical Support

Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC₅₀s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells.

For research use only. We do not sell to patients.

Linifanib Chemical Structure

CAS No. : 796967-16-3

Size	Stock	Quantity
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Linifanib:

Linifanib-d₄ Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All VEGFR Isoform Specific Products:

View All Isoforms

VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

View All PDGFR Isoform Specific Products:

View All Isoforms

PDGFR PDGFRβ PDGFRα

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 4 nM (KDR), 4 nM (FLT1), 66 nM (PDGFRβ), 3 nM (CSF-1R), 4 nM (FLT3), 14 nM (Kit)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8343 nM Compound: Linifanib	Antiproliferative activity activity human A549 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity activity human A549 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
EA.hy 926	IC₅₀	2.48 μM Compound: ABT-869	Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay	[PMID: 32750566]
HL-60	IC₅₀	7880 nM Compound: Linifanib	Antiproliferative activity against human HL-60 cells harboring wildtype FLT3 assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity against human HL-60 cells harboring wildtype FLT3 assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
HUVEC	IC₅₀	40.11 μM Compound: Linifanib	Antiproliferative activity against HUVEC after 72 hrs by cell titer glo-based fluorescence assay Antiproliferative activity against HUVEC after 72 hrs by cell titer glo-based fluorescence assay	[PMID: 30121211]
HUVEC	IC₅₀	4920 nM Compound: Linifanib	Cytotoxicity against HUVEC cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Cytotoxicity against HUVEC cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
HepG2	IC₅₀	4001 nM Compound: Linifanib	Antiproliferative activity activity human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity activity human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
K562	GI₅₀	> 20 μM Compound: ABT-869, 4	Antiproliferation activity against human K562 cells expressing wild type BCR/ABL after 72 hrs by MTS method Antiproliferation activity against human K562 cells expressing wild type BCR/ABL after 72 hrs by MTS method	[PMID: 21708468]
K562	IC₅₀	6963 nM Compound: Linifanib	Cytotoxicity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
MCF7	IC₅₀	17.03 μM Compound: Linifanib	Antiproliferative activity against human MCF7 cells after 72 hrs by cell titer glo-based fluorescence assay Antiproliferative activity against human MCF7 cells after 72 hrs by cell titer glo-based fluorescence assay	[PMID: 30121211]
MOLM-13	GI₅₀	0.037 μM Compound: 3, ABT-869	Cytotoxicity against human MOLM13 cells harboring mutant FLT3 after 72 hrs by MTS assay Cytotoxicity against human MOLM13 cells harboring mutant FLT3 after 72 hrs by MTS assay	[PMID: 23618709]
MOLM-13	GI₅₀	0.037 μM Compound: ABT-869, 4	Antiproliferation activity against human MOLM13 cells expressing FLT3 mutation assessed as cell viability after 72 hrs by MTS method Antiproliferation activity against human MOLM13 cells expressing FLT3 mutation assessed as cell viability after 72 hrs by MTS method	[PMID: 21708468]
MOLM-13	GI₅₀	37 nM Compound: 3, ABT-869	Antiproliferative activity against human MOLM13 cells expressing FLT3-ITD mutant Antiproliferative activity against human MOLM13 cells expressing FLT3-ITD mutant	[PMID: 22726931]
MOLM-13	IC₅₀	19 nM Compound: Linifanib	Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
MOLT-4	GI₅₀	6.7 μM Compound: ABT-869, 4	Antiproliferation activity against human MOLT4 after 72 hrs by MTS method Antiproliferation activity against human MOLT4 after 72 hrs by MTS method	[PMID: 21708468]
MV4-11	GI₅₀	0.04 μM Compound: ABT-869, 4	Antiproliferation activity against FLT3/ITD harboring human MV4-11 cells after 72 hrs by MTS method Antiproliferation activity against FLT3/ITD harboring human MV4-11 cells after 72 hrs by MTS method	[PMID: 21708468]
MV4-11	IC₅₀	0.69 μM Compound: Linifanib	Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer glo-based fluorescence assay Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer glo-based fluorescence assay	[PMID: 30121211]
MV4-11	IC₅₀	3.4 nM Compound: Linifanib	Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
NFS-60	GI₅₀	4.4 μM Compound: ABT-869	Growth inhibition of mouse NFS-60 cells incubated for 72 hrs by Cell titer-glo assay Growth inhibition of mouse NFS-60 cells incubated for 72 hrs by Cell titer-glo assay	[PMID: 36335744]
NFS-60	IC₅₀	30 nM Compound: ABT-869	Cytotoxicity against mouse NFS-60 cells assessed as cell growth inhibition incubated for 72 hrs by Cell titer-glo assay Cytotoxicity against mouse NFS-60 cells assessed as cell growth inhibition incubated for 72 hrs by Cell titer-glo assay	[PMID: 36335744]
NIH3T3	IC₅₀	4 nM Compound: 17p, ABT-869	Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA	[PMID: 17343372]
RAW264.7	IC₅₀	8.6 μM Compound: ABT-869	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36335744]
RPMI-8226	IC₅₀	5889.4 nM Compound: Chemical probe : ABT-869	Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferation assay Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferation assay	[PMID: 26254279]
RS4-11	GI₅₀	9.2 μM Compound: ABT-869, 4	Antiproliferation activity against human RS4:11 cells expressing wild type FLT3 after 72 hrs by MTS method Antiproliferation activity against human RS4:11 cells expressing wild type FLT3 after 72 hrs by MTS method	[PMID: 21708468]
Sf9	IC₅₀	0.005 μM Compound: ABT-869, 4	Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.007 μM Compound: 3, ABT-869	Inhibition of recombinant GST tagged VEGFR2 (789 to 1356) (unknown origin) transfected in insect sf9 cells after 120 mins by wallac counting analysis Inhibition of recombinant GST tagged VEGFR2 (789 to 1356) (unknown origin) transfected in insect sf9 cells after 120 mins by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.02 μM Compound: 3, ABT-869	Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysis Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.02 μM Compound: ABT-869, 4	Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assay Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.037 μM Compound: ABT-869, 4	Inhibition of recombinant GST-tagged VEGFR1 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged VEGFR1 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.76 μM Compound: 3, ABT-869	Inhibition of recombinant GST tagged Aurora A kinase (123 to 401) (unknown origin) transfected in insect sf9 cells after 90 mins by wallac counting analysis Inhibition of recombinant GST tagged Aurora A kinase (123 to 401) (unknown origin) transfected in insect sf9 cells after 90 mins by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.76 μM Compound: ABT-869, 4	Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assay	[PMID: 21708468]
U-937	GI₅₀	19 μM Compound: ABT-869, 4	Antiproliferation activity against human FLT3 gene-deficient U937 cells after 72 hrs by MTS method Antiproliferation activity against human FLT3 gene-deficient U937 cells after 72 hrs by MTS method	[PMID: 21708468]

In Vitro

Linifanib (GMP) (1 μM) induces generation of hCiPS cells from human embryonic fibroblasts (HEFs)^[1].
Linifanib (GMP) (1 μM) induces generation of hCiPS cells from hADSCs or hASFs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

375.40

Formula

C₂₁H₁₈FN₅O

CAS No.

796967-16-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (274 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605(7909):325-331. [Content Brief]

Linifanib Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linifanib (GMP)796967-16-3ABT-869 (GMP)AL-39324 (GMP)VEGFRPDGFRVascular endothelial growth factor receptorPlatelet-derived growth factor receptorGMPcell therapydifferentiatesomatic celltransdifferentiatehCiPSreprogrammingInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Linifanib (Synonyms: ABT-869; AL-39324)

Customer Review

Other Forms of Linifanib:

Linifanib Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All VEGFR Isoform Specific Products:

View All PDGFR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Linifanib Related Antibodies

Linifanib Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report