Cat. No.: HY-50751G

Linifanib (GMP)

Name: Linifanib (GMP)
Brand: MedChemExpress
SKU: HY-50751G
Price: 1260.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ABT-869 (GMP); AL-39324 (GMP))

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Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC₅₀s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells.

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CAS No.: 796967-16-3
Formule: C₂₁H₁₈FN₅O
Masse moléculaire:375.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Linifanib (GMP) Chemical Structure

CAS No.: 796967-16-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC50: 4 nM (KDR), 4 nM (FLT1), 66 nM (PDGFRβ), 3 nM (CSF-1R), 4 nM (FLT3), 14 nM (Kit)^[1]

Voir tous les produits spécifiques à Isoform VEGFR :

Voir tous les produits spécifiques à Isoform PDGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8343 nM Compound: Linifanib	Antiproliferative activity activity human A549 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity activity human A549 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
EA.hy 926	IC₅₀	2.48 μM Compound: ABT-869	Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay	[PMID: 32750566]
HepG2	IC₅₀	4001 nM Compound: Linifanib	Antiproliferative activity activity human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity activity human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
HL-60	IC₅₀	7880 nM Compound: Linifanib	Antiproliferative activity against human HL-60 cells harboring wildtype FLT3 assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity against human HL-60 cells harboring wildtype FLT3 assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
HUVEC	IC₅₀	40.11 μM Compound: Linifanib	Antiproliferative activity against HUVEC after 72 hrs by cell titer glo-based fluorescence assay Antiproliferative activity against HUVEC after 72 hrs by cell titer glo-based fluorescence assay	[PMID: 30121211]
HUVEC	IC₅₀	4920 nM Compound: Linifanib	Cytotoxicity against HUVEC cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Cytotoxicity against HUVEC cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
K562	GI₅₀	>20 μM Compound: ABT-869, 4	Antiproliferation activity against human K562 cells expressing wild type BCR/ABL after 72 hrs by MTS method Antiproliferation activity against human K562 cells expressing wild type BCR/ABL after 72 hrs by MTS method	[PMID: 21708468]
K562	IC₅₀	6963 nM Compound: Linifanib	Cytotoxicity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
MCF7	IC₅₀	17.03 μM Compound: Linifanib	Antiproliferative activity against human MCF7 cells after 72 hrs by cell titer glo-based fluorescence assay Antiproliferative activity against human MCF7 cells after 72 hrs by cell titer glo-based fluorescence assay	[PMID: 30121211]
MOLM-13	GI₅₀	0.037 μM Compound: 3, ABT-869	Cytotoxicity against human MOLM13 cells harboring mutant FLT3 after 72 hrs by MTS assay Cytotoxicity against human MOLM13 cells harboring mutant FLT3 after 72 hrs by MTS assay	[PMID: 23618709]
MOLM-13	GI₅₀	0.037 μM Compound: ABT-869, 4	Antiproliferation activity against human MOLM13 cells expressing FLT3 mutation assessed as cell viability after 72 hrs by MTS method Antiproliferation activity against human MOLM13 cells expressing FLT3 mutation assessed as cell viability after 72 hrs by MTS method	[PMID: 21708468]
MOLM-13	GI₅₀	37 nM Compound: 3, ABT-869	Antiproliferative activity against human MOLM13 cells expressing FLT3-ITD mutant Antiproliferative activity against human MOLM13 cells expressing FLT3-ITD mutant	[PMID: 22726931]
MOLM-13	IC₅₀	19 nM Compound: Linifanib	Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
MOLT-4	GI₅₀	6.7 μM Compound: ABT-869, 4	Antiproliferation activity against human MOLT4 after 72 hrs by MTS method Antiproliferation activity against human MOLT4 after 72 hrs by MTS method	[PMID: 21708468]
MV4-11	GI₅₀	0.04 μM Compound: ABT-869, 4	Antiproliferation activity against FLT3/ITD harboring human MV4-11 cells after 72 hrs by MTS method Antiproliferation activity against FLT3/ITD harboring human MV4-11 cells after 72 hrs by MTS method	[PMID: 21708468]
MV4-11	IC₅₀	0.69 μM Compound: Linifanib	Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer glo-based fluorescence assay Antiproliferative activity against human MV4-11 cells after 72 hrs by cell titer glo-based fluorescence assay	[PMID: 30121211]
MV4-11	IC₅₀	3.4 nM Compound: Linifanib	Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay	[PMID: 35863236]
NFS-60	GI₅₀	4.4 μM Compound: ABT-869	Growth inhibition of mouse NFS-60 cells incubated for 72 hrs by Cell titer-glo assay Growth inhibition of mouse NFS-60 cells incubated for 72 hrs by Cell titer-glo assay	[PMID: 36335744]
NFS-60	IC₅₀	30 nM Compound: ABT-869	Cytotoxicity against mouse NFS-60 cells assessed as cell growth inhibition incubated for 72 hrs by Cell titer-glo assay Cytotoxicity against mouse NFS-60 cells assessed as cell growth inhibition incubated for 72 hrs by Cell titer-glo assay	[PMID: 36335744]
NIH3T3	IC₅₀	4 nM Compound: 17p, ABT-869	Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA	[PMID: 17343372]
RAW264.7	IC₅₀	8.6 μM Compound: ABT-869	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36335744]
RPMI-8226	IC₅₀	5889.4 nM Compound: Chemical probe : ABT-869	Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferation assay Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferation assay	[PMID: 26254279]
RS4-11	GI₅₀	9.2 μM Compound: ABT-869, 4	Antiproliferation activity against human RS4:11 cells expressing wild type FLT3 after 72 hrs by MTS method Antiproliferation activity against human RS4:11 cells expressing wild type FLT3 after 72 hrs by MTS method	[PMID: 21708468]
Sf9	IC₅₀	0.005 μM Compound: ABT-869, 4	Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.007 μM Compound: 3, ABT-869	Inhibition of recombinant GST tagged VEGFR2 (789 to 1356) (unknown origin) transfected in insect sf9 cells after 120 mins by wallac counting analysis Inhibition of recombinant GST tagged VEGFR2 (789 to 1356) (unknown origin) transfected in insect sf9 cells after 120 mins by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.02 μM Compound: 3, ABT-869	Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysis Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.02 μM Compound: ABT-869, 4	Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assay Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.037 μM Compound: ABT-869, 4	Inhibition of recombinant GST-tagged VEGFR1 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged VEGFR1 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay	[PMID: 21708468]
Sf9	IC₅₀	0.76 μM Compound: 3, ABT-869	Inhibition of recombinant GST tagged Aurora A kinase (123 to 401) (unknown origin) transfected in insect sf9 cells after 90 mins by wallac counting analysis Inhibition of recombinant GST tagged Aurora A kinase (123 to 401) (unknown origin) transfected in insect sf9 cells after 90 mins by wallac counting analysis	[PMID: 23618709]
Sf9	IC₅₀	0.76 μM Compound: ABT-869, 4	Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assay Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assay	[PMID: 21708468]
U-937	GI₅₀	19 μM Compound: ABT-869, 4	Antiproliferation activity against human FLT3 gene-deficient U937 cells after 72 hrs by MTS method Antiproliferation activity against human FLT3 gene-deficient U937 cells after 72 hrs by MTS method	[PMID: 21708468]

In Vitro

Linifanib (GMP) (1 μM) induces generation of hCiPS cells from human embryonic fibroblasts (HEFs)^[1].
Linifanib (GMP) (1 μM) induces generation of hCiPS cells from hADSCs or hASFs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 796967-16-3
Appearance Solid
Masse moléculaire 375.40
Formule C₂₁H₁₈FN₅O
Color White to off-white
SMILES

O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F
Synonyms

ABT-869 (GMP); AL-39324 (GMP)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605(7909):325-331. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Linifanib (GMP)

Voir tous les produits spécifiques à Isoform VEGFR

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